ArticleDiabetologia2004
Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes.
Article in Diabetologia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 68 citations in OpenAlex.
- Trial
- De novo lipogenesis and cholesterol synthesis in humans with long-standing type 1 diabetes are comparable to non-diabetic individuals.PloS one · 2013Trial
- Increased LDL-C reduction with ezetimibe in ketogenic diet-induced hypercholesterolemia.Lipids in health and disease · 2026Article
- Article
- Strategies to reduce cholesterol content in poultry eggs: an overview.Tropical animal health and production · 2026Review
- Article
- Article
- Review
- ABCG5 and ABCG8: more than a defense against xenosterols.Journal of lipid research · 2018Review
- Administration of CORM-2 inhibits diabetic neuropathy but does not reduce dyslipidemia in diabetic mice.PloS one · 2018Article
- Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity.European journal of drug metabolism and pharmacokinetics · 2016Review
- Nonlinear transcriptomic response to dietary fat intake in the small intestine of C57BL/6J mice.BMC genomics · 2016Article
- Dyslipidaemia of diabetes and the intestine.World journal of diabetes · 2015Review
- Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.Seminars in liver disease · 2013Review
- Isolation and biochemical analysis of vesicles from taurohyodeoxycholic acid-infused isolated perfused rat livers.World journal of gastroenterology · 2013Article
- Prioritization of candidate disease genes by topological similarity between disease and protein diffusion profiles.BMC bioinformatics · 2013Article
- Type I diabetes mellitus decreases in vivo macrophage-to-feces reverse cholesterol transport despite increased biliary sterol secretion in mice.Journal of lipid research · 2012Article
- The chylomicron: relationship to atherosclerosis.International journal of vascular medicine · 2012Article
- Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study.Journal of lipid research · 2010Article
- Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols.Pflugers Archiv : European journal of physiology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aim/hypothesisType I diabetes is associated with altered hepatic bile formation and increased intestinal cholesterol absorption. The aim of this study was to evaluate whether altered expression of the ATP-Binding Cassette half-transporters Abcg5 and Abcg8, recently implicated in control of both hepatobiliary cholesterol secretion and intestinal cholesterol absorption, contributes to changed cholesterol metabolism in experimental diabetes.
methodsmRNA and protein expression of Abcg5 and Abcg8 were determined in the liver and intestine of rats with streptozotozin-induced diabetes and related to relevant metabolic parameters in plasma, liver and bile.
resultsHepatic mRNA expression of both Abcg5 (-76%) and Abcg8 (-71%) was reduced in diabetic rats when compared to control rats. In spite of increased HDL cholesterol, considered a major source of biliary cholesterol, secretion of the sterol into bile relative to that of bile salts was reduced by 65% in diabetic animals. Intestinal mRNA expression of Abcg5 (-47%) and Abcg8 (-43%) as well as Abcg5 protein contents were also reduced in insulin-deficient animals. This was accompanied by a three- to four-fold increase in plasma beta-sitosterol and campesterol concentrations and by a doubling of the calculated apparent cholesterol absorption. These effects partially normalized upon insulin supplementation. CONCLUSION/
interpretationOur data indicate that effects of insulin-deficiency on bile composition and cholesterol absorption in rats are, at least partly, attributable to changes in hepatic and intestinal Abcg5 and Abcg8 expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.