ArticleVirus genes2003
Absence of p53 alterations in nasopharyngeal carcinoma Spanish patients with Epstein-Barr virus infection.
Article in Virus genes, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- Heterozygous p53-R280T Mutation Enhances the Oncogenicity of NPC Cells Through Activating PI3K-Akt Signaling Pathway.Frontiers in oncology · 2020Article
- Involvement of the Epstein-Barr virus in the nasopharyngeal carcinoma pathogenesis.Medical oncology (Northwood, London, England) · 2005Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
The objective of this study was to analyse the relationships between the Epstein-Barr virus (EBV) infection and the molecular abnormalities of the p53 oncoprotein in the nasopharyngeal carcinoma (NPC). Fifty-five NPC paraffin samples from a group of Spanish patients with EBV demonstrated presence by nested-PCR and non-isotopic in situ hybridisation, were analysed for p53 expression using immunohistochemistry. The positive samples by immunohistochemistry were studied for p53 gene alterations in the exon 5 by single strand conformation polymorphism (SSCP). Among the 55 specimens, 14 (25.5%) showed expression of p53 protein. All these positive samples corresponded to the late stage of the tumour. Of the 14 samples, p53 gene alterations were found only in three cases using SSCP. These results indicate that the p53 mutations are an infrequent event in NPC in Spanish patients needing exogenous factors as the EBV infection for the development of this malignancy.
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