ArticleJournal of computational neuroscience
AHP's, HAP's and DAP's: how potassium currents regulate the excitability of rat supraoptic neurones.
Article in Journal of computational neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 75 citations in OpenAlex.
- Endoplasmic Reticulum and Mitochondrial Calcium Handling Dynamically Shape Slow Afterhyperpolarizations in Vasopressin Magnocellular Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Phasic Neuronal Firing in the Rodent Nucleus of the Solitary TractFrontiers in physiology · 2021Article
- From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells.International journal of molecular sciences · 2019Article
- Electrophysiological properties of identified oxytocin and vasopressin neurones.Journal of neuroendocrinology · 2019Review
- Specificity in the interaction of high-voltage-activated CaJournal of neurophysiology · 2018Article
- Changes in potassium channel modulation may underlie afterhyperpolarization plasticity in oxytocin neurons during late pregnancy.Journal of neurophysiology · 2018Article
- Phosphatidylinositol 4,5-bisphosphate (PIPThe Journal of physiology · 2017Article
- Concise Whole-Cell Modeling of BKBiophysical journal · 2017Article
- Spike patterning in oxytocin neurons: Capturing physiological behaviour with Hodgkin-Huxley and integrate-and-fire models.PloS one · 2017Article
- Nitric Oxide Modulates HCN Channels in Magnocellular Neurons of the Supraoptic Nucleus of Rats by an S-Nitrosylation-Dependent Mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Oxytocin Neurones: Intrinsic Mechanisms Governing the Regularity of Spiking Activity.Journal of neuroendocrinology · 2016Article
- Review: CaThe open neurology journal · 2016Article
- Modeling the cellular mechanisms and olfactory input underlying the triphasic response of moth pheromone-sensitive projection neurons.PloS one · 2015Article
- Diverse roles of G-protein coupled receptors in the regulation of neurohypophyseal hormone secretion.Journal of neuroendocrinology · 2012Review
- Epithelial Na⁺ sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei.American journal of physiology. Endocrinology and metabolism · 2012Article
- Phasic firing in vasopressin cells: understanding its functional significance through computational models.PLoS computational biology · 2012Article
- New determinants of firing rates and patterns of vasopressinergic magnocellular neurons: predictions using a mathematical model of osmodetection.Journal of computational neuroscience · 2011Article
- Biocytin-labelling and its impact on late 20th century studies of cortical circuitry.Brain research reviews · 2011Article
- Ion channels and signaling in the pituitary gland.Endocrine reviews · 2010Review
- Calcium-dependent control of temporal processing in an auditory interneuron: a computational analysis.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We have constructed mathematical models of the electrical activity of two hypothalamic supraoptic neuro-secretory cell-types, and we support our models with new calcium imaging and in vitro electrophysiological data. These cells are neurones that project to the pituitary gland and secrete either of two hormones, oxytocin or vasopressin, into the blood from their axonal terminals. Oxytocin-secreting and vasopressin-secreting cells are closely related and physically they differ only subtly, however when physiologically stressed their discharge patterns are dramatically distinct. We first show how each potassium current contributes to the action-potentials and after-potentials observed in these cells, and we show how these after-potentials are correlated to intra-cellular calcium elevations. We then show how these currents regulate the excitability of these cells and consequently shape their discharge pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.