ArticleMolecular biology of the cell2004
Involvement of the AP-1 adaptor complex in early steps of phagocytosis and macropinocytosis.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Flavescence dorée phytoplasma enters insect cells by a clathrin-mediated endocytosis allowing infection of its insect vector.Scientific reports · 2023Article
- Multifaceted control of E-cadherin dynamics by Adaptor Protein Complex 1 during epithelial morphogenesis.Molecular biology of the cell · 2022Article
- Defective Phagocytic Properties of HIV-Infected Macrophages: How Might They Be Implicated in the Development of InvasiveFrontiers in immunology · 2018Review
- WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Olive (Olea europaea) leaf extract induces apoptosis and monocyte/macrophage differentiation in human chronic myelogenous leukemia K562 cells: insight into the underlying mechanism.Oxidative medicine and cellular longevity · 2014Article
- The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility.Cell communication and signaling : CCS · 2013Article
- Structural disorder provides increased adaptability for vesicle trafficking pathways.PLoS computational biology · 2013Article
- Endocytic pathways involved in filovirus entry: advances, implications and future directions.Viruses · 2012Review
- A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization.Traffic (Copenhagen, Denmark) · 2012Article
- Distinct and overlapping roles for AP-1 and GGAs revealed by the "knocksideways" system.Current biology : CB · 2012Article
- Phospholipase A2 mediates apolipoprotein-independent uptake of chylomicron remnant-like particles by human macrophages.International journal of vascular medicine · 2012Article
- Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes.Molecular biology of the cell · 2011Article
- Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7.PLoS pathogens · 2010Article
- Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors.PLoS pathogens · 2010Article
- The origins of phagocytosis and eukaryogenesis.Biology direct · 2009Article
- AP-1 and ARF1 control endosomal dynamics at sites of FcR mediated phagocytosis.Molecular biology of the cell · 2007Article
- Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology.Molecular and biochemical parasitologyReview
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The best described function of the adaptor complex-1 (AP-1) is to participate in the budding of clathrin-coated vesicles from the trans-Golgi network and endosomes. Here, we show that AP-1 is also localized to phagocytic cups in murine macrophages as well as in Dictyostelium amoebae. AP-1 is recruited to phagosomal membranes at this early stage of phagosome formation and rapidly dissociates from maturing phagosomes. To establish the role of AP-1 in phagocytosis, we made used of Dictyostelium mutant cells (apm1(-) cells) disrupted for AP-1 medium chain. In this mutant, phagocytosis drops by 60%, indicating that AP-1 is necessary for efficient phagocytosis. Furthermore, phagocytosis in apm1(-) cells is more affected for large rather than small particles, and cells exhibiting incomplete engulfment are then often observed. This suggests that AP-1 could participate in the extension of the phagocytic cup. Interestingly, macropinocytosis, a process dedicated to fluid-phase endocytosis and related to phagocytosis, is also impaired in apm1(-) cells. In summary, our data suggest a new role of AP-1 at an early stage of phagosome and macropinosome formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.