ArticleThe Journal of clinical investigation2003
Hyperosmolarity enhances the lung capillary barrier.
Article in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Mechanobiological Adaptation to Hyperosmolarity Enhances Barrier Function in Human Vascular Microphysiological System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Admission serum sodium and osmolarity are not associated with the occurrence or outcomes of acute respiratory distress syndrome in critically ill.Journal of critical care · 2023Article
- Epidemiology and Outcomes of Hypernatraemia in Patients with COVID-19-A Territory-Wide Study in Hong Kong.Journal of clinical medicine · 2023Article
- Hypertonic treatment of acute respiratory distress syndrome.Frontiers in bioengineering and biotechnology · 2023Article
- The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury.Nature communications · 2022Article
- Induced hypernatremia in patients with moderate-to-severe ARDS: a randomized controlled study.Intensive care medicine experimental · 2021Article
- A Missense Genetic Variant in LRRC16A/CARMIL1 Improves Acute Respiratory Distress Syndrome Survival by Attenuating Platelet Count Decline.American journal of respiratory and critical care medicine · 2017Article
- The ten studies that should be done in ARDS.Intensive care medicine · 2016Article
- Role played by paxillin and paxillin tyrosine phosphorylation in hepatocyte growth factor/sphingosine-1-phosphate-mediated reactive oxygen species generation, lamellipodia formation, and endothelial barrier function.Pulmonary circulation · 2015Article
- Effect of hypertonic saline treatment on the inflammatory response after hydrochloric acid-induced lung injury in pigs.Clinics (Sao Paulo, Brazil) · 2015Article
- Article
- IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Endothelial connexin43 mediates acid-induced increases in pulmonary microvascular permeability.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Cadherin selectivity filter regulates endothelial sieving properties.Nature communications · 2012Article
- Cross talk between focal adhesion kinase and cadherins: role in regulating endothelial barrier function.Microvascular research · 2012Review
- Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact.The American journal of pathology · 2011Article
- Paracrine purinergic signaling determines lung endothelial nitric oxide production.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Protective effects of high-molecular weight polyethylene glycol (PEG) in human lung endothelial cell barrier regulation: role of actin cytoskeletal rearrangement.Microvascular research · 2009Article
- Article
- Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy.American journal of respiratory cell and molecular biology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Although capillary barrier deterioration underlies major inflammatory lung pathology, barrier-enhancing strategies are not available. To consider hyperosmolar therapy as a possible strategy, we gave 15-minute infusions of hyperosmolar sucrose in lung venular capillaries imaged in real time. Surprisingly, this treatment enhanced the capillary barrier, as indicated by quantification of the capillary hydraulic conductivity. The barrier enhancement was sufficient to block the injurious effects of thrombin, TNF-alpha, and H2O2 in single capillaries, and of intratracheal acid instillation in the whole lung. Capillary immunofluorescence indicated that the hyperosmolar infusion markedly augmented actin filament formation and E-cadherin expression at the endothelial cell periphery. The actin-depolymerizing agent latrunculin B abrogated the hyperosmolar barrier enhancement as well as the actin filament formation, suggesting a role for actin in the barrier response. Furthermore, hyperosmolar infusion blocked TNF-alpha-induced P-selectin expression in an actin-dependent manner. Our results provide the first evidence to our knowledge that in lung capillaries, hyperosmolarity remodels the endothelial barrier and the actin cytoskeleton to enhance barrier properties and block proinflammatory secretory processes. Hyperosmolar therapy may be beneficial in lung inflammatory disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.