ArticleThe Journal of physiology2004
Synapses between parallel fibres and stellate cells express long-term changes in synaptic efficacy in rat cerebellum.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 102 citations in OpenAlex.
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- Cerebellar basket cell filtering of Purkinje cell responses elicited by low frequency parallel fibre transmission.Scientific reports · 2025Article
- Article
- Advances in the Pathogenesis of Auto-antibody-Induced Cerebellar Synaptopathies.Cerebellum (London, England) · 2023Review
- Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Gating by Memory: a Theory of Learning in the Cerebellum.Cerebellum (London, England) · 2022Article
- The Cerebellar Cortex.Annual review of neuroscience · 2022Review
- How and Why the Cerebellum Recodes Input Signals: An Alternative to Machine Learning.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
- Cerebellar Circuits for Classical Fear Conditioning.Frontiers in cellular neuroscience · 2022Review
- Gating by Functionally Indivisible Cerebellar Circuits: a Hypothesis.Cerebellum (London, England) · 2021Article
- Physiology of Cerebellar Reserve: Redundancy and Plasticity of a Modular Machine.International journal of molecular sciences · 2021Review
- Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum.Scientific reports · 2021Article
- Molecular layer interneurons in the cerebellum encode for valence in associative learning.Nature communications · 2020Article
- Cannabinoid agonist administration within the cerebellar cortex impairs motor learning.Neurobiology of learning and memory · 2020Review
- Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo.Cell reports · 2020Article
- Long-term depression of presynaptic cannabinoid receptor function at parallel fibre synapses.The Journal of physiology · 2019Article
- Diverse Neuron Properties and Complex Network Dynamics in the Cerebellar Cortical Inhibitory Circuit.Frontiers in molecular neuroscience · 2019Article
- Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum.Neuron · 2018Article
- Activity-dependent plasticity of presynaptic GABASynapse (New York, N.Y.) · 2018Article
- Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve.CNS & neurological disorders drug targets · 2018Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various forms of synaptic plasticity underlying motor learning have already been well characterized at cerebellar parallel fibre (PF)-Purkinje cell (PC) synapses. Inhibitory interneurones play an important role in controlling the excitability and synchronization of PCs. We have therefore tested the possibility that excitatory synapses between PFs and stellate cells (SCs) are also able to exhibit long-term changes in synaptic efficacy. In the present study, we show that long-term potentiation (LTP) and long-term depression (LTD) were induced at these synapses by a low frequency stimulation protocol (2 Hz for 60 s) and that pairing this low frequency stimulation protocol with postsynaptic depolarization induced a marked shift of synaptic plasticity in favour of LTP. This LTP was cAMP independent, but required nitric oxide (NO) production from pre- and/or postsynaptic elements, depending on the stimulation or pairing protocol used, respectively. In contrast, LTD was not dependent on NO production but it required activation of postsynaptic group II and possibly of group I metabotropic glutamate receptors. Finally, stimulation of PFs at 8 Hz for 15 s also induced LTP at PF-SC synapses. But in this case, LTP was cAMP dependent, as was also observed at PF-PC synapses for presynaptic LTP induced in the same conditions. Thus, long-term changes in synaptic efficacy can be accomplished by PF-SCs synapses as well as by PF-PC synapses, suggesting that both types of plasticity might co-operate during cerebellar motor learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.