ArticleBMC developmental biology2003
Expression of the Hsp23 chaperone during Drosophila embryogenesis: association to distinct neural and glial lineages.
Article in BMC developmental biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Ecdysteroid responses to urban heat island conditions during development of the western black widow spider (Latrodectus hesperus).PloS one · 2022Article
- Small heat shock proteins determine synapse number and neuronal activity during development.PloS one · 2020Article
- Drosophila Hsp67Bc hot-spot variants alter muscle structure and function.Cellular and molecular life sciences : CMLS · 2018Article
- Developmental Expression and Functions of the Small Heat Shock Proteins inInternational journal of molecular sciences · 2018Review
- Identification and expression analysis of multiple small heat shock protein genes in spruce budworm, Choristoneura fumiferana (L.).Cell stress & chaperones · 2018Article
- Maternal loading of a small heat shock protein increases embryo thermal tolerance inThe Journal of experimental biology · 2017Article
- Oligomeric structure and chaperone-like activity of Drosophila melanogaster mitochondrial small heat shock protein Hsp22 and arginine mutants in the alpha-crystallin domain.Cell stress & chaperones · 2017Article
- Small heat shock proteins mediate cell-autonomous and -nonautonomous protection in a Drosophila model for environmental-stress-induced degeneration.Disease models & mechanisms · 2016Article
- Stress Responses of Small Heat Shock Protein Genes in Lepidoptera Point to Limited Conservation of Function across Phylogeny.PloS one · 2015Article
- Heat shock proteins and Drosophila aging.Experimental gerontology · 2011Review
- Characterization of the shsp genes in Drosophila buzzatii and association between the frequency of Valine mutations in hsp23 and climatic variables along a longitudinal gradient in Australia.Cell stress & chaperones · 2010Article
- Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila.Genome biology · 2008Article
- Differences in the chaperone-like activities of the four main small heat shock proteins of Drosophila melanogaster.Cell stress & chaperones · 2006Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn addition to their strong induction following stress, small heat shock proteins (Hsp) are also expressed during development in a wide variety of organisms. However, the precise identity of cell(s) expressing these proteins and the functional contribution of small heat shock proteins in such developmental context remain to be determined. The present study provides a detailed description of the Drosophila small heat shock protein Hsp23 expression pattern during embryogenesis and evaluates its functional contribution to central nervous system development.
resultsThroughout embryogenesis, Hsp23 is expressed in a stage-specific manner by a restricted number of neuronal and glial lineages of the central nervous system. Hsp23 is also detected in the amnioserosa and within a single lateral chordotonal organ. Its expression within the MP2 lineage does not require the presence of a functional midline nor the activity of the Notch signaling pathway. Transactivation assays demonstrate that transcription factors implicated in the differentiation of the midline also regulate hsp23 promoter activity. Phenotypic analysis of a transgenic line exhibiting loss of Hsp23 expression in the central nervous system suggests that Hsp23 is not required for development and function of this tissue. Likewise, its overexpression does not cause deleterious effects, as development remains unaffected.
conclusionsBased on the presented data, we suggest that the tightly regulated developmental expression of Hsp23 is not actively involved in cell differentiation and central nervous system development per se but rather reflects a putative role in preventive "pre-stress" neuroprotection or in non-vital process(es) common to the identified cell lineages.
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