ArticleClinical and experimental immunology2003
Anti-annexin V antibodies in Takayasu's arteritis: prevalence and relationship with disease activity.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- Autoantibody-Based Models for the Diagnosis and Activity Assessment of Takayasu Arteritis.Journal of cardiovascular translational research · 2026Article
- ANXA5: related mechanisms of osteogenesis and additional biological functions.Frontiers in cell and developmental biology · 2025Review
- A Glimpse into Humoral Response and Related Therapeutic Approaches of Takayasu's Arteritis.International journal of molecular sciences · 2024Review
- A Rare Case of Anca Positivity and Antiphospholipid Antibodies in a Patient with Takayasu Arteritis: Case Report and Review of the Literature.Biomedicines · 2023Article
- Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritis.Arthritis research & therapy · 2023Article
- Outcome Measures and Biomarkers for Disease Assessment in Takayasu Arteritis.Diagnostics (Basel, Switzerland) · 2022Review
- Takayasu arteritis: a cohort of Italian patients and recent pathogenetic and therapeutic advances.Clinical and experimental medicine · 2021Article
- Childhood-Onset Takayasu Arteritis (c-TA): Current and Future Drug Therapy.Paediatric drugs · 2019Review
- Takayasu arteritis - epidemiology, pathogenesis, diagnosis and treatment.Journal of applied biomedicine · 2019Review
- Biomarkers in Vasculitides of the Nervous System.Frontiers in neurology · 2019Review
- Serum BAFF and APRIL levels in Indian patients with Takayasu arteritis.Clinical rheumatology · 2018Article
- Article
- Association of ferritin antibodies with Takayasu arteritis.Clinical rheumatology · 2014Article
- Annexin A5 and anti-annexin antibodies in patients with systemic lupus erythematosus.Rheumatology international · 2012Article
- Development of outcome measures for large-vessel vasculitis for use in clinical trials: opportunities, challenges, and research agenda.The Journal of rheumatology · 2011Article
- Anti-endothelial cell antibodies are prevalent in juvenile idiopathic arthritis: implications for clinical disease course and pathogenesis.Rheumatology international · 2007Article
- Takayasu's arteritis: A case report and a brief review of the literature.Heart international · 2006Article
- Anti-endothelial cell antibodies (AECA) in patients with propylthiouracil (PTU)-induced ANCA positive vasculitis are associated with disease activity.Clinical and experimental immunology · 2005Article
- Cellular and humoral immune responses to mycobacterial heat shock protein-65 and its human homologue in Takayasu's arteritis.Clinical and experimental immunology · 2004Article
- Cytokine mRNA repertoire of peripheral blood mononuclear cells in Takayasu's arteritis.Clinical and experimental immunology · 2004Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Annexin V has an important role in the regulation of apoptosis and antibodies directed against it have been shown to lead to apoptosis of vascular endothelial cells. To evaluate the role of anti-annexin V antibodies (AA5A) in Takayasu's arteritis (TA), we investigated these antibodies in the sera of 66 TA patients, 50 healthy controls and in the follow-up sera of 12 active TA patients by enzyme-linked immunosorbent assay. The AA5A-positive patients were analysed further for the presence of anti-endothelial cell antibodies (AECA) and anticardiolipin antibodies (ACLA) to determine the relationship of AA5A with these autoantibodies. AA5A were observed in 36% (24/66) of the patients versus 6% (3/50) of the controls (P<0.001) and in 53% (19/36) of patients with active TA versus 17% (5/30) of those with inactive disease (P<0.01). Levels of AA5A were also observed to be significantly higher in patients with TA compared to controls (0.557 +/- 0.362 versus 0.259 +/- 0.069; P<0.0001) and in patients with active disease compared to those with inactive disease (0.700 +/- 0.403 versus 0.385 +/- 0.205; P<0.0001). In the follow-up study, 6/12 patients who became inactive during follow-up also showed normalization of AA5A levels. AECA and ACLA were detected in 54% (13/24) and 12% (3/24) of the AA5A-positive patients, respectively. Our results show that a significant proportion of TA patients have AA5A, which exhibit an association with AECA and because they have a correlation with disease activity thus appear to be involved in the disease pathogenesis.
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