ArticleClinical and experimental immunology2003
Effects of deviating the Th2-response in murine mercury-induced autoimmunity towards a Th1-response.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 35 citations in OpenAlex.
- Snow White's tale in nephrology: the emerging threat of skin-whitening creams on kidney health.Clinical kidney journal · 2025Review
- Maternal gestational mercury exposure in relation to cord blood T cell alterations and placental gene expression signatures.Environmental research · 2021Article
- Mercury as a cause of membranous nephropathy and Guillain-Barre syndrome: case report and literature review.The Journal of international medical research · 2021Review
- Shuang-Huang-Lian prevents basophilic granulocyte activation to suppress Th2 immunity.BMC complementary and alternative medicine · 2018Article
- Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity.PloS one · 2014Article
- Lupus-like oral mucosal lesions in mercury-induced autoimmune response in Brown Norway rats.BMC immunology · 2013Article
- STAT4-dependent and -independent Th2 responses correlate with protective immunity against lung infection with Pneumocystis murina.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Mercury exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study.Environmental research · 2010Article
- Mercury-induced membranous nephropathy: clinical and pathological features.Clinical journal of the American Society of Nephrology : CJASN · 2010Article
- Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro.Environmental health perspectives · 2009Article
- Immunomodulation by mercuric chloride in vitro: application of different cell activation pathways.Clinical and experimental immunology · 2007Article
- Interleukin-10 in murine metal-induced systemic autoimmunity.Clinical and experimental immunology · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T-helper cells type 1 (Th1) and type 2 (Th2) play an important role in the pathogenesis of autoimmune diseases. In many Th1-dependent autoimmune models, treatment with recombinant interleukin-12 (rIL-12) accelerates the autoimmune response. Mercury-induced autoimmunity (HgIA) in mice is an H-2 regulated condition with antinucleolar antibodies targeting fibrillarin (ANoA), systemic immune-complex (IC) deposits and transient polyclonal B-cell activation (PBA). HgIA has many characteristics of a Th2 type of reaction, including a strong increase of IgE, but disease induction is critically dependent on the Th1 cytokine IFN-gamma. The aim of this study was to investigate if a strong deviation of the immune response in HgIA towards Th1 would aggravate HgIA. Injections of both rIL-12 and anti-IL-4 monoclonal antibody (alpha-IL-4) reduced the HgCl2-(Hg-)induced concentration of the Th2-dependent serum IgE and IgG1, but increased the Th1-dependent serum IgG2a. The IgG-ANoA developed earlier and attained a higher titre after combined treatment, and the ANoA titre of the IgG1 isotype decreased while the ANoA titre of the Th1-associated IgG2a, IgG2b and IgG3-ANoA isotypes increased. Treatment with rIL-12 alone increased the Hg-induced IgG2a and IgG3 ANoA titres, the PBA, and the IC deposits in renal and splenic vessel walls, while treatment with alpha-IL-4 + Hg inhibited renal but not splenic vessel wall IC deposits. We conclude that manipulating the cytokine status, by altering the Th1/Th2 balance, will influence autoimmune disease manifestations. This might be an important way of modulating human autoimmune diseases.
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