ArticleProceedings of the National Academy of Sciences of the United States of America2003
Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Article
- Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging.Biomedicines · 2023Review
- The Genetic Variability ofGenes · 2019Review
- The Impact of Aging on Cardio and Cerebrovascular Diseases.International journal of molecular sciences · 2018Review
- Apolipoprotein C-I Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Population.International journal of environmental research and public health · 2017Article
- Paraoxonase-1 (PON1) rs662 Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Zhuang Population.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study.BMC geriatrics · 2016Article
- Familial Risk for Exceptional Longevity.North American actuarial journal : NAAJ · 2016Article
- Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.Circulation research · 2015Article
- Insights from human congenital disorders of intestinal lipid metabolism.Journal of lipid research · 2015Review
- Serum BPIFB4 levels classify health status in long-living individuals.Immunity & ageing : I & A · 2015Article
- Who are the Okinawans? Ancestry, genome diversity, and implications for the genetic study of human longevity from a geographically isolated population.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- We are ageing.BioMed research international · 2014Review
- Genetics of healthy aging and longevity.Human genetics · 2013Review
- Article
- Microsomal triglyceride transfer protein gene -493G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China.Lipids in health and disease · 2012Article
- Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Cognitive decline and dementia in the oldest-old.Rambam Maimonides medical journal · 2012Article
- The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations.Immunity & ageing : I & A · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
We previously reported a genomewide linkage study for human longevity using 308 long-lived individuals (LLI) (centenarians or near-centenarians) in 137 sibships and identified statistically significant linkage within chromosome 4 near microsatellite D4S1564. This interval spans 12 million bp and contains approximately 50 putative genes. To identify the specific gene and gene variants impacting lifespan, we performed a haplotype-based fine-mapping study of the interval. The resulting genetic association study identified a haplotype marker within microsomal transfer protein as a modifier of human lifespan. This same variant was tested in a second cohort of LLI from France, and although the association was not replicated, there was evidence for statistical distortion in the form of Hardy-Weinberg disequilibrium. Microsomal transfer protein has been identified as the rate-limiting step in lipoprotein synthesis and may affect longevity by subtly modulating this pathway. This study provides proof of concept for the feasibility of using the genomes of LLI to identify genes impacting longevity.
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