ArticleVirchows Archiv : an international journal of pathology2003
Plasmacytoid cells in salivary-gland pleomorphic adenomas: evidence of luminal cell differentiation.
Article in Virchows Archiv : an international journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 42 citations in OpenAlex.
- A Mouthful of Genomic Data: Single-Cell Insights into Salivary Gland Biology and Disease.Biology · 2026Review
- Correlation of Clinical and Histopathological Features of Salivary Pleomorphic Adenoma.Journal of dentistry (Shiraz, Iran) · 2023Article
- Knockdown of lncRNA ENST00000603829 Inhibits the Proliferation and Invasion of Salivary Gland Pleomorphic Adenoma through Regulating Cyclin D1.Applied bionics and biomechanics · 2022Article
- Immunolocalization patterns of cytokeratins during salivary acinar cell development in mice.Journal of molecular histology · 2018Article
- Epithelial Markers aSMA, Krt14, and Krt19 Unveil Elements of Murine Lacrimal Gland Morphogenesis and Maturation.Frontiers in physiology · 2017Article
- Functional Histology of Salivary Gland Pleomorphic Adenoma: An Appraisal.Head and neck pathology · 2015Review
- Myoepithelioma of minor salivary glands - A diagnostic challenge: Report of three cases with varied histomorphology.Journal of oral and maxillofacial pathology : JOMFP · 2013Article
- Plasmacytoid myoepithelioma of minor salivary glands: report of case with emphasis in the immunohistochemical findings.Head & face medicine · 2011Article
- Label-retaining cells in the rat submandibular gland.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- Epithelial and stromal patterns of pleomorphic adenoma of minor salivary glands: A histopathological and histochemical study.Journal of oral and maxillofacial pathology : JOMFPArticle
- Myoepithelioma of minor salivary gland--an immunohistochemical analysis of four cases.Brazilian journal of otorhinolaryngologyArticle
- The ultrastructural aspects of neoplastic myoepithelial cell in pleomorphic adenomas of salivary glands.Journal of cellular and molecular medicineArticle
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7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the cellular origin of plasmacytoid cells in salivary gland adenomas, immunohistochemistry was performed on sections from 12 pleomorphic adenomas rich in these cells. In normal salivary glands included in these sections, the myoepithelial cells (MECs) expressed alpha-smooth muscle actin (alphaSMA) and smooth muscle myosin heavy chain (SMMHC), whereas the duct luminal cells expressed keratins 19, 18 and 8. Some of the salivary duct basal cells expressed these keratins, and the acinar cells expressed keratins 18 and 8. The expression profile was similar in rat salivary glands not only after but also during development. The immature MECs never expressed the keratins nor did the immature duct cells express alphaSMA. In seven cases, up to 60% of the plasmacytoid cells expressed keratin 19. In three of these cases, about 10% of the plasmacytoid cells expressed keratin 18. No plasmacytoid cells expressed alphaSMA, SMMHC or keratin 8. These results indicate that plasmacytoid cells originate from luminal cells and not from MECs. Furthermore, in addition to the luminal tumor cells, the non-luminal cells could express keratins 19, 18 and 8. Therefore, it is necessary to re-evaluate the prevailing notion that non-luminal cells are modified MECs. Keratin 14, basic calponin, vimentin and p63 were bi-specific for the MECs and the duct cells. Therefore, expression of these proteins by significant numbers of the non-luminal tumor cells and the plasmacytoid cells never denied the above notion.
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