IA-2 is not required for the development of diabetes in NOD mice.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

20 citing papers in PubMed.

1. Rituximab selectively suppresses specific islet antibodies.Diabetes · 2011
   Trial
2. The beta cell-immune cell interface in type 1 diabetes (T1D).Molecular metabolism · 2023
   Review
3. Monitoring immunomodulation strategies in type 1 diabetes.Frontiers in immunology · 2023
   Review
4. Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice.Drug delivery · 2022
   Article
5. Determining Antigen Specificity of Human Islet Infiltrating T Cells in Type 1 Diabetes.Frontiers in immunology · 2019
   Review
6. Autoimmune Responses to Exosomes and Candidate Antigens Contribute to Type 1 Diabetes in Non-Obese Diabetic Mice.Current diabetes reports · 2017
   Review
7. Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.Diabetes · 2017
   Article
8. T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes.Frontiers in endocrinology · 2017
   Review
9. Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes.Journal of immunology (Baltimore, Md. : 1950) · 2016
   Article
10. Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity.Diabetes care · 2013
    Article
11. Type 1 diabetes: primary antigen/peptide/register/trimolecular complex.Immunologic research · 2013
    Review
12. Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice.Diabetes · 2012
    Article
13. Insulin as a key autoantigen in the development of type 1 diabetes.Diabetes/metabolism research and reviews · 2011
    Review
14. T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives.Clinical & developmental immunology · 2011
    Review
15. Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Diabetes · 2010
    Article
16. Conserved T cell receptor alpha-chain induces insulin autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2008
    Article
17. Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes.Clinical and experimental immunology · 2007
    Review
18. An immunologic homunculus for type 1 diabetes.The Journal of clinical investigation · 2006
    Article
19. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.Nature · 2005
    Article
20. Antigen-based vs. systemic immunomodulation in type 1 diabetes: the pros and cons.Islets
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as