ArticleOncogene2003
AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Review
- Exploring effective biomarkers and potential immune related gene in small cell lung cancer.Scientific reports · 2024Article
- Establishment and validation of a novel prognostic model for lower-grade glioma based on senescence-related genes.Frontiers in immunology · 2022Article
- ZNF655 Promotes the Progression of Glioma Through Transcriptional Regulation of AURKA.Frontiers in oncology · 2022Article
- Review
- Aurora kinase A inhibitor TCS7010 demonstrates pro-apoptotic effect through the unfolded protein response pathway in HCT116 colon cancer cells.Oncology letters · 2017Article
- Modelling of the cancer cell cycle as a tool for rational drug development: A systems pharmacology approach to cyclotherapy.PLoS computational biology · 2017Article
- Mitosis as an anti-cancer drug target.Chromosoma · 2013Review
- Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.Molecular oncology · 2013Article
- p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs.SpringerPlus · 2013Article
- Adenovirus-mediated Aurora A shRNA driven by stathmin promoter suppressed tumor growth and enhanced paclitaxel chemotherapy sensitivity in human breast carcinoma cells.Cancer gene therapy · 2012Article
- Aurora kinase-C-T191D is constitutively active mutant.BMC cell biology · 2012Article
- Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest.Cell cycle (Georgetown, Tex.) · 2012Article
- Effects of stable knockdown of Aurora kinase A on proliferation, migration, chromosomal instability, and expression of focal adhesion kinase and matrix metalloproteinase-2 in HEp-2 cells.Molecular and cellular biochemistry · 2011Article
- A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis.Frontiers in oncology · 2011Article
- Suppression of Aurora-A oncogenic potential by c-Myc downregulation.Experimental & molecular medicine · 2010Article
- Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP).Pediatric blood & cancer · 2010Article
- Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.EMBO molecular medicine · 2010Article
- Aurora kinase inhibitors--rising stars in cancer therapeutics?Molecular cancer therapeutics · 2010Review
- RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner.Oncogene · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AuroraA, a mitotic kinase, is reported to be amplified and overexpressed in a variety of human tumors. Active mutants of AuroraA can transform mouse fibroblasts and form tumors in nude mice. However, the mechanism behind this oncogenic potential remains elusive. In this study, we investigated the consequences of AuroraA overexpression and showed that increased AuroraA levels compromise the mitotic spindle checkpoint triggered by nocodazole, a microtubule polymerization inhibitor. This is accomplished by disrupting the proper assembly of the mitotic checkpoint complex at the level of the Cdc20-BubR1 interaction. As a result, the spindle checkpoint complex fails to form and cells progress through mitosis without proper arrest in response to nocodazole. This ability to override the mitotic spindle checkpoint was found to be independent of AuroraA kinase activity. We conclude that maintenance of a functional balance between AuroraA and mitotic checkpoint proteins is essential for the proper progression through mitosis. This study therefore offers a possible explanation of how deregulation of AuroraA can contribute to genetic instability and tumorigenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.