ArticleGenome research2003
Correlations between gene expression and gene conservation in fission yeast.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation.Development (Cambridge, England) · 2023Article
- Variables Influencing Differences in Sequence Conservation in the Fission Yeast Schizosaccharomyces pombe.Journal of molecular evolution · 2021Article
- Stress-induced expression is enriched for evolutionarily young genes in diverse budding yeasts.Nature communications · 2020Article
- Nannochloropsis genomes reveal evolution of microalgal oleaginous traits.PLoS genetics · 2014Article
- Transcriptome map of plant mitochondria reveals islands of unexpected transcribed regions.BMC genomics · 2011Article
- Community transcriptomics reveals universal patterns of protein sequence conservation in natural microbial communities.Genome biology · 2011Article
- Analysis of the Basidiomycete Coprinopsis cinerea reveals conservation of the core meiotic expression program over half a billion years of evolution.PLoS genetics · 2010Article
- Meiotic regulators Ndt80 and ime2 have different roles in Saccharomyces and Neurospora.Genetics · 2010Article
- Dynamic changes in protein functional linkage networks revealed by integration with gene expression data.PLoS computational biology · 2008Article
- urg1: a uracil-regulatable promoter system for fission yeast with short induction and repression times.PloS one · 2008Article
- Gene discovery and transcript analyses in the corn smut pathogen Ustilago maydis: expressed sequence tag and genome sequence comparison.BMC genomics · 2007Article
- LymphTF-DB: a database of transcription factors involved in lymphocyte development.Genes and immunity · 2007Article
- A network of multiple regulatory layers shapes gene expression in fission yeast.Molecular cell · 2007Article
- Comparative proteomic and transcriptomic profiling of the fission yeast Schizosaccharomyces pombe.Molecular systems biology · 2007Article
- Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.Genome biology · 2007Article
- Simplified primer design for PCR-based gene targeting and microarray primer database: two web tools for fission yeast.Yeast (Chichester, England) · 2006Article
- Changes in gene expression during male meiosis in Petunia hybrida.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Article
- A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.Current biology : CB · 2005Article
- Comparison of the yeast proteome to other fungal genomes to find core fungal genes.Journal of molecular evolution · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Genes can be expressed at a wide range of levels, and they show different degrees of cross-species conservation. We compared gene expression levels to gene conservation by integrating microarray data from fission yeast (Schizosaccharomyces pombe) with lists of "core" genes (present in worm and budding and fission yeasts), "yeast-specific" genes (present in budding and fission yeasts, but not in worm), and "pombe-specific" genes (present in fission yeast only). Whereas a disproportionate number of core genes are highly expressed in vegetatively growing cells, many pombe-specific genes are expressed at lower levels. This bias is less pronounced in cells undergoing sexual development, when many pombe-specific genes become highly expressed. This implies that organism-specific proteins are more likely to function during specialized processes such as cellular differentiation. Accordingly, pombe-specific genes were overrepresented among genes induced during sexual development; they were particularly enriched in a group of genes induced during meiotic prophase, when homologous chromosomes pair and recombine. This raises the possibility that organism-specific genes with functions in meiotic prophase favor speciation by preventing fruitful meiosis between closely related organisms. Finally, the set of genes induced late during sexual differentiation, at the time of spore formation, was enriched in yeast-specific genes, indicating that these genes play specialized roles in ascospore development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.