ArticleLipids in health and disease2003
Insulin sensitivity and Lp(alpha) concentrations in normoglycemic offspring of type 2 diabetic parents.
Article in Lipids in health and disease, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Defects in oxygen supply to skeletal muscle of prediabetic ZDF rats.American journal of physiology. Heart and circulatory physiology · 2010Article
- Insulin inhibits human erythrocyte cAMP accumulation and ATP release: role of phosphodiesterase 3 and phosphoinositide 3-kinase.Experimental biology and medicine (Maywood, N.J.) · 2010Article
- Beta cell (dys)function in non-diabetic offspring of diabetic patients.Diabetologia · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOffspring of at least 1 parent with type 2 diabetes are more resistant to the insulin action, exhibit higher incidence of dyslipidemia and are more prone to cardiovascular diseases. The association between Lp(alpha) and coronary heart disease is well established. An association between Lp(alpha) concentration and insulin sensitivity was examined in this study. We investigated the serum LP(alpha) in 41 offspring of 41 families of type 2 diabetic subjects (group I) with normal glucose tolerance, compared to 49 offspring who their parents had no history of type 2 diabetes, matched for sex, age, BMI, WHR and blood pressure (group II). Serum Lp(alpha), triglycerides, insulin resistant index, HDL, LDL-cholesterol and insulin were measured.
resultsThe offspring of type 2 diabetic subjects had higher fasting serum triglycerides (mean +/- SD 199.3 +/- 184.2 vs. 147.1 +/- 67.9 ng/dl, p < 0.05) lower HDL-cholesterol (37.3 +/- 9.0 vs. 44.6 +/- 7.8, p < 0.001) and particularly higher Insulin resistance Index (HOMA-IR) (2.84 +/- 1.39 vs. 1.67 +/- 0.77, p < 0.001). They also had higher serum LP(alpha) concentration (15.4 +/- 6.7 vs. 8.6 +/- 6.0, p < 0.001). By simple linear analysis in the offspring of type 2 diabetic parents there was no correlation of Lp(alpha) concentration with insulin resistance index Homa-IR (r = 0,016 p = NS).
conclusionsWe conclude that serum LP(alpha) is significantly increased in offspring of type 2 diabetic subjects but was not related to insulin sensitivity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.