ArticleBritish journal of cancer2003
Differential expression profiling of head and neck squamous cell carcinoma (HNSCC).
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
- Clusterin in Head and Neck Squamous Cell Carcinoma: Diagnostic, Prognostic, and Therapeutic Implications.Current oncology reports · 2026Review
- Development and experimental verification of a prognosis model for hypoxia- and lactate metabolism-associated genes in HNSCC.Medicine · 2025Article
- The Potential Role of SP-G and PLUNC in Tumor Pathogenesis and Wound Healing in the Human Larynx.Biomedicines · 2025Article
- Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma.Journal of personalized medicine · 2023Review
- Cell death in head and neck cancer pathogenesis and treatment.Cell death & disease · 2021Review
- Sensitivity to Cisplatin in Head and Neck Cancer Cells Is Significantly Affected by Patient-Derived Cancer-Associated Fibroblasts.International journal of molecular sciences · 2021Article
- Article
- Integrated Analysis RevealsFrontiers in oncology · 2020Article
- Profiling dendritic cell subsets in head and neck squamous cell tonsillar cancer and benign tonsils.Scientific reports · 2018Article
- P4HA1: A single-gene surrogate of hypoxia signatures in oral squamous cell carcinoma patients.Clinical and translational radiation oncology · 2017Article
- Mutation and Transcriptional Profiling of Formalin-Fixed Paraffin Embedded Specimens as Companion Methods to Immunohistochemistry for Determining Therapeutic Targets in Oropharyngeal Squamous Cell Carcinoma (OPSCC): A Pilot of Proof of Principle.Head and neck pathology · 2015Article
- Bactericidal/Permeability-increasing protein fold-containing family member A1 in airway host protection and respiratory disease.American journal of respiratory cell and molecular biology · 2015Review
- Microarray analysis of serum mRNA in patients with head and neck squamous cell carcinoma at whole-genome scale.BioMed research international · 2014Article
- APOBEC3 deletion polymorphism is associated with breast cancer risk among women of European ancestry.Carcinogenesis · 2013Article
- Immunohistochemistry, a valuable tool in detection of cervical lymph node micrometastases in head and neck squamous cell carcinoma: a prospective study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2013Article
- A common deletion in the APOBEC3 genes and breast cancer risk.Journal of the National Cancer Institute · 2013Article
- Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay.Archives of oral biology · 2012Article
- Gene expression profiling of oral squamous cell carcinoma by differential display rt-PCR and identification of tumor biomarkers.Indian journal of surgical oncology · 2010Article
- Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma.Journal of natural products · 2010Article
- ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines.British journal of cancer · 2010Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head and neck squamous cell carcinoma (HNSCC) is the fifth most common cancer in men with an incidence of about 780000 new cases per year worldwide and a poor rate of survival. There is a need for a better understanding of HNSCC, for the development of rational targeted interventions and to define new prognostic or diagnostic markers. To address these needs, we performed a large-scale differential display comparison of hypopharyngeal HNSCCs against histologically normal tissue from the same patients. We have identified 70 genes that exhibit a striking difference in expression between tumours and normal tissues. There is only a limited overlap with other HNSCC gene expression studies that have used other techniques and more heterogeneous tumour samples. Our results provide new insights into the understanding of HNSCC. At the genome level, a series of differentially expressed genes cluster at 12p12-13 and 1q21, two hotspots of genome disruption. The known genes share functional relationships in keratinocyte differentiation, angiogenesis, immunology, detoxification, and cell surface receptors. Of particular interest are the 13 'unknown' genes that exist only in EST, theoretical cDNA and protein databases, or as chromosomal locations. The differentially expressed genes that we have identified are potential new markers and therapeutic targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.