ArticleBritish journal of cancer2003
Gene expression profiling identifies tumour markers potentially playing a role in uveal melanoma development.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 85 citations in OpenAlex.
- Gene Therapy Strategies for Uveal Melanoma: Adeno-associated Virus Delivery Challenges and Translational Opportunities.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Review
- Multidimensional immune ecological subtyping identifies RUNX1 as a prognostic factor in uveal melanoma.Discover oncology · 2026Article
- Using ovine eyes as a readily available source for the isolation and 2D or 3D cultivation of uveal melanocytes.PloS one · 2026Article
- Identification of diagnostic and prognostic genetic alterations in uveal melanoma using RNA sequencing.Scientific reports · 2025Article
- Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma.BMC biology · 2025Article
- Natural killer cells drive 4-1BBL positive uveal melanoma towards EMT and metastatic disease.Journal of experimental & clinical cancer research : CR · 2024Article
- PRAME Expression: A Target for Cancer Immunotherapy and a Prognostic Factor in Uveal Melanoma.Investigative ophthalmology & visual science · 2023Article
- The biology of uveal melanoma.Cancer metastasis reviews · 2017Review
- Article
- Ocular tumors: Triumphs, challenges and controversies.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society · 2013Article
- Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.The Journal of clinical investigation · 2013Article
- The pathology of ocular cancer.Eye (London, England) · 2013Review
- Additive, non-additive and maternal effects of cytokine transcription in response to immunostimulation with Vibrio vaccine in Chinook salmon (Oncorhynchus tshawytscha).Immunogenetics · 2012Article
- The genetics of uveal melanoma: an emerging framework for targeted therapy.Pigment cell & melanoma research · 2012Review
- Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials.PloS one · 2012Article
- Article
- Expression profiling of formalin-fixed paraffin embedded primary human uveal melanomas using DASL matrices.Journal of cancer research and clinical oncology · 2010Article
- Expression of the SST receptor 2 in uveal melanoma is not a prognostic marker.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2008Article
- Triamcinolone acetonide and anecortave acetate do not stimulate uveal melanoma cell growth.Molecular vision · 2008Article
- Reduced expression of autotaxin predicts survival in uveal melanoma.The British journal of ophthalmology · 2007Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microarray is a powerful tool to compare the gene expression of different tumour specimens and cell lines simultaneously and quantitatively. To get a better insight into genes that are involved in uveal melanoma tumorigenesis, we compared the gene expression profiles of 12 different uveal melanoma cell lines with three melanocyte cell cultures obtained from healthy donor eyes. Gene expression profiles were obtained by nylon filter arrays, containing 1176 gene spots related to cancer development. The expression levels of selected genes were validated on cell lines and primary uveal melanomas by real time RT-PCR, and were subsequently included in cluster analysis. Four candidate tumour markers, Laminin Receptor 1, Endothelin 2, Von Hippel Lindau Binding protein 1 and Cullin 2, have been selected from genes that were differentially expressed in the uveal melanoma cell lines compared to the normal uveal melanocytes. In primary uveal melanomas, these four markers could discriminate between two classes of uveal melanoma, which may be indicative of a differential disease process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.