ArticleProceedings of the National Academy of Sciences of the United States of America2003
Biomolecular mimicry in the actin cytoskeleton: mechanisms underlying the cytotoxicity of kabiramide C and related macrolides.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 92 citations in OpenAlex.
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- Human Nanoplatelets as Living Vehicles for Tumor-Targeted Endocytosis In Vitro and Imaging In Vivo.Journal of clinical medicine · 2023Article
- Next Generation Opto-Jasplakinolides Enable Local Remodeling of Actin Networks.Angewandte Chemie (International ed. in English) · 2022Article
- Actin-Associated Proteins and Small Molecules Targeting the Actin Cytoskeleton.International journal of molecular sciences · 2022Review
- Tetrapyrrolic Pigments from Heme- and Chlorophyll Breakdown are Actin-Targeting Compounds.Angewandte Chemie (International ed. in English) · 2021Article
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- Bioactive Compounds from Marine Heterobranchs.Marine drugs · 2020Review
- Actin stabilizing compounds show specific biological effects due to their binding mode.Scientific reports · 2019Article
- Iriomoteolides: novel chemical tools to study actin dynamics.Chemical science · 2018Article
- Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.Medicinal research reviews · 2017Review
- Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass.Journal of natural products · 2017Article
- Human platelets repurposed as vehicles for in vivo imaging of myeloma xenotransplants.Oncotarget · 2016Article
- Regulation of ECM degradation and axon guidance by growth cone invadosomes.Development (Cambridge, England) · 2015Article
- Evolution of a unified, stereodivergent approach to the synthesis of communesin F and perophoramidine.The Journal of organic chemistry · 2015Article
- Structural and biochemical studies of actin in complex with synthetic macrolide tail analogues.ChemMedChem · 2014Article
- PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowth.Journal of cell science · 2013Article
- Antimicrobial secondary metabolites from marine gastropod egg capsules and egg masses.Asian Pacific journal of tropical biomedicine · 2012Article
- Molecular docking and QSAR of aplyronine A and analogues: potent inhibitors of actin.Journal of computer-aided molecular design · 2010Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study characterizes the interactions between kabiramide C (KabC) and related macrolides and actin and establishes the mechanisms that underlie their inhibition of actin filament dynamics and cytotoxicity. The G-actin-KabC complex is formed through a two-step binding reaction and is extremely stable and long-lived. Competition-binding studies show that KabC binds to the same site on G-actin as Gelsolin domain 1 and CapG. KabC also binds to protomers within F-actin and results in the severing and capping of the (+) end; these studies suggest that free KabC and related macrolides act as biomimetics of Gelsolin. The G-actin-KabC complex binds to the (+) end of a growing filament, where it functions as a novel, unregulated, (+)-end capper and is largely responsible for the inhibition of motility and cytokinesis in approximately 10 -100 nM KabC-treated cells. KabC and related macrolides are useful probes to study the regulation of the actin filament (+) end and may lead to new therapies to treat diseases of the actin cytoskeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.