ArticleMolecular and cellular biology2003
Rapid, stabilizing palindrome rearrangements in somatic cells by the center-break mechanism.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Non-B DNA structures and their contributions to genetic diversity, aging, and disease.Nucleic acids research · 2026Review
- A unifying model that explains the origins of human inverted copy number variants.PLoS genetics · 2024Review
- Review
- Molecular mechanisms and topological consequences of drastic chromosomal rearrangements of muntjac deer.Nature communications · 2021Article
- A reference catalog of DNA palindromes in the human genome and their variations in 1000 Genomes.Human genome variation · 2020Article
- The 22q11 low copy repeats are characterized by unprecedented size and structural variability.Genome research · 2019Article
- A pilot study on the prevalence of DNA palindromes in breast cancer genomes.BMC medical genomics · 2016Article
- Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences.Nucleic acids research · 2016Article
- Short Inverted Repeats Are Hotspots for Genetic Instability: Relevance to Cancer Genomes.Cell reports · 2015Article
- Mechanisms of gene duplication and amplification.Cold Spring Harbor perspectives in biology · 2015Review
- DNA secondary structure at chromosomal fragile sites in human disease.Current genomics · 2015Article
- SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements.Molecular biology of the cell · 2014Article
- Breakpoint analysis of the recurrent constitutional t(8;22)(q24.13;q11.21) translocation.Molecular cytogenetics · 2014Article
- De novo-generated small palindromes are characteristic of amplicon boundary junction of double minutes.International journal of cancer · 2013Article
- Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations.Nature communications · 2013Article
- Nonspaced inverted DNA repeats are preferential targets for homology-directed gene repair in mammalian cells.Nucleic acids research · 2012Article
- Self-catalyzed site-specific depurination of G residues mediated by cruciform extrusion in closed circular DNA plasmids.The Journal of biological chemistry · 2011Article
- A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction: the t(8;22)(q24.13;q11.21).American journal of human genetics · 2010Article
- E. coli SbcCD and RecA control chromosomal rearrangement induced by an interrupted palindrome.Molecular cell · 2010Article
- Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells.Human molecular genetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA palindromes are associated with rearrangement in a variety of organisms. A unique opportunity to examine the impact of a long palindrome in mammals is afforded by the Line 78 strain of mice. Previously it was found that the transgene in Line 78 is likely to be palindromic and that the symmetry of the transgene was responsible for a high level of germ line instability. Here we prove that Line 78 mice harbor a true 15.4-kb palindrome, and through the establishment of cell lines from Line 78 mice we have shown that the palindrome rearranges at the impressive rate of about 0.5% per population doubling. The rearrangements observed to arise from rapid palindrome modification are consistent with a center-break mechanism where double-strand breaks, created through hairpin nicking of an extruded cruciform, are imprecisely rejoined, thus introducing deletions at the palindrome center. Significantly, palindrome rearrangements in somatic tissue culture cells almost completely mirrored the structures generated in vivo in the mouse germ line. The close correspondence between germ line and somatic events indicates the possibility that center-break modification of palindromes is an important mechanism for preventing mutation in both contexts. Permanent cell lines carrying a verified palindrome provide an essential tool for future mechanistic analyses into the consequences of palindromy in the mammalian genome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.