ArticleMolecular and cellular biology2003
Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Jade1 and the HBO1 histone acetyltransferase complex are spatial-selective cofactors of the pluripotency transcription factor Oct4.The Journal of biological chemistry · 2025Article
- Maternal hypoxia exposure perturbs imprinted gene methylation in adult sperm and induces intergenerational placental impairments in male offspring.Zoological research · 2025Article
- Genetic Association and Differential RNA Expression of Histone (De)Acetylation-Related Genes in Pemphigus Foliaceus-A Possible Epigenetic Effect in the Autoimmune Response.Life (Basel, Switzerland) · 2023Article
- Identifying novel regulators of placental development using time-series transcriptome data.Life science alliance · 2023Article
- ExcessiveFrontiers in cell and developmental biology · 2021Article
- Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals.Journal of cellular biochemistry · 2019Article
- GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Review
- Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.Science translational medicine · 2016Article
- Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse.Nature genetics · 2015Article
- What does genetics tell us about imprinting and the placenta connection?Cellular and molecular life sciences : CMLS · 2015Review
- The novel function of JADE1S in cytokinesis of epithelial cells.Cell cycle (Georgetown, Tex.) · 2015Article
- Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex.Cell cycle (Georgetown, Tex.) · 2014Article
- A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation.The EMBO journal · 2013Article
- Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma.Cancer research · 2013Article
- Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration.The American journal of pathology · 2013Article
- Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1.Human molecular genetics · 2012Article
- Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains.BMC genomics · 2012Article
- Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex.The Journal of biological chemistry · 2008Article
- Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a gene trap screen for genes expressed in the primitive streak and tail bud during mouse embryogenesis, we isolated a mutation in Jade1, a gene encoding a PHD zinc finger protein previously shown to interact with the tumor suppressor pVHL. Expressed sequence tag analysis indicates that Jade1 is subject to posttranscriptional regulation, resulting in multiple transcripts and at least two protein isoforms. The fusion Jade1-beta-galactosidase reporter produced by the gene trap allele exhibits a regulated expression during embryogenesis and localizes to the nucleus and/or cytoplasm of different cell types. In addition to the primitive streak and tail bud, beta-galactosidase activity was found in other embryonic regions where pluripotent or tissue-specific progenitors are known to reside, including the early gastrulation epiblast and the ventricular zone of the cerebral cortex. Prominent reporter expression was also seen in the extraembryonic tissues as well as other differentiated cell types in the embryo, in particular the developing musculature. We show that the gene trap mutation produces a null allele. However, homozygotes for the gene trap integration are viable and fertile. Database searches identified a family of Jade proteins conserved through vertebrates. This raises the possibility that the absence of phenotype is due to a functional compensation by other family members.
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