Evidence map›Paper›PMID 14610524›Full record

ReviewMolecular psychiatry2004

Will haplotype maps be useful for finding genes?

E J C G van den Oord, B M Neale

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Genomic prediction with haplotype blocks in wheat.Frontiers in plant science · 2023
    Article
  3. Review
  4. Article
  5. A HapMap harvest of insights into the genetics of common disease.The Journal of clinical investigation · 2008
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

E J C G van den OordVirginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA, USA. ejvandenoord@vcu.edu
B M Neale

Funding

Candidate Genes in Models of Mental HealthR01MH065320 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI VAN DEN OORD, EDWIN · 2003 to 2005
$938k
NIMH NIH HHS MH065320
6 · The paper itself

Abstract

From its introduction into the literature, the idea of haplotype map-based linkage disequilibrium (LD) studies has been the subject of disputes. These queries involve the extent to which the haplotype blocks exist, the validity of fundamental concepts such as the recombination hotspot, and the application of this idea in the form of the HapMap project. In this article, we review the relevant literature to evaluate the potential importance of haplotype maps for psychiatric genetics. We first take a closer look at the nature of haplotype blocks and then address the impact of block definitions and methodological factors, such as single-nucleotide polymorphism density and sample size, on findings from haplotype block studies. After distinguishing between two types of haplotype map-based LD studies, we discuss the importance of the recombination hotspot and the nature of the disease mutations affecting complex traits. In the final section, we summarize our main conclusions and comment on the usefulness of haplotype maps for finding genes.

Indexed as

GenesHaplotypesChromosome MappingHumansLinkage DisequilibriumPolymorphism, Single Nucleotide

Identifiers

PMID14610524

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.