ReviewImmunologic research2003
Human genetics of common mycobacterial infections.
Review in Immunologic research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Association ofFrontiers in immunology · 2020Article
- Landscape of the genome and host cell response of Mycobacterium shigaense reveals pathogenic features.Emerging microbes & infections · 2018Article
- Small RNAs in mycobacteria: an unfolding story.Frontiers in cellular and infection microbiology · 2014Review
- Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment.Tuberculosis research and treatment · 2013Article
- Tagging single nucleotide polymorphisms in the IRF1 and IRF8 genes and tuberculosis susceptibility.PloS one · 2012Article
- Leprosy and the human genome.Microbiology and molecular biology reviews : MMBR · 2010Review
- An automated framework for understanding structural variations in the binding grooves of MHC class II molecules.BMC bioinformatics · 2010Article
- Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction.PLoS neglected tropical diseases · 2008Article
- Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.The Journal of infectious diseases · 2008Article
- Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.PloS one · 2007Article
- Mycobacterium tuberculosis, macrophages, and the innate immune response: does common variation matter?Immunological reviews · 2007Review
- Tuberculosis Infection: Insight from Immunogenomics.Drug discovery today. Disease mechanisms · 2007Article
- Mannan-binding lectin plasma levels in leprosy: deficiency confers protection against the lepromatous but not the tuberculoid forms.Clinical and experimental immunology · 2006Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing interest in and understanding of the role of human genetic factors controlling susceptibility/resistance to infectious diseases. This is of particular importance for the two most common mycobacterial infections, tuberculosis and leprosy, because this will allow a genetic dissection of antimycobacterial immunity and should open new fields of preventive and therapeutic measures. In this review we will initially discuss various methods of genetic epidemiology that have been and are being developed to identify human genes controlling infectious diseases, and then illustrate the findings obtained in the numerous studies performed in tuberculosis and leprosy. Although the most convincing results were observed for HLA-DR2 and NRAMP1 (or a closely linked gene) in pulmonary tuberculosis and leprosy subtypes and for a 10p13 locus in paucibacillary leprosy, the molecular basis of their effects remains to be established.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.