ArticleProceedings of the National Academy of Sciences of the United States of America2003
Circadian modulation of long-term sensitization in Aplysia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 62 citations in OpenAlex.
- Examining the impact of adolescent social isolation on oxycodone sensitization.Psychopharmacology · 2026Article
- The Right Time for a Synapse to Change: Windows and Mechanisms of Multiday Training Trials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Effects of training protocols that do not induce long-term sensitization on the expression of long-term feeding suppression in Aplysia.Physiology & behavior · 2025Article
- The circadian genes are required in DAL neurons forFrontiers in neuroscience · 2025Article
- Circadian disruption of memory consolidation inFrontiers in systems neuroscience · 2023Article
- Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.Cellular signalling · 2021Review
- Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Article
- Role of nitric oxide in the induction of the behavioral and cellular changes produced by a common aversive stimulus in Aplysia.Behavioural brain research · 2019Article
- Effects of internal and external factors on the budgeting between defensive and non-defensive responses in Aplysia.Behavioural brain research · 2018Article
- miR-132 couples the circadian clock to daily rhythms of neuronal plasticity and cognition.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Clocking In Time to Gate Memory Processes: The Circadian Clock Is Part of the Ins and Outs of Memory.Neural plasticity · 2018Review
- Sleep supports inhibitory operant conditioning memory inLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Constant Light Desynchronizes Olfactory versus Object and Visuospatial Recognition Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Chronic sleep deprivation differentially affects short and long-term operant memory in Aplysia.Neurobiology of learning and memory · 2016Article
- SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory.Nature communications · 2016Article
- Synchrony and desynchrony in circadian clocks: impacts on learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
- Article
- A time to remember: the role of circadian clocks in learning and memory.Behavioral neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
As the mechanisms for learning and memory are elucidated, modulation of learning and memory becomes a central issue. We studied the modulation of learning and memory by investigating the circadian regulation of short- and long-term sensitization of the siphon withdrawal reflex in Aplysia. We found that Aplysia exhibited diurnal and circadian rhythms of long-term sensitization (LTS) with significantly greater LTS occurring when animals were trained and tested during the day relative to those trained and tested at night. In contrast to the modulation of LTS, short-term sensitization was not regulated by the circadian clock. Time of training rather than time of testing determined the circadian rhythm of LTS. Animals trained during the subjective day demonstrated LTS when tested during either the day or the night. Conversely, when animals were trained during the night, LTS was not observed when animals were tested either at night or during the day. Thus, the circadian rhythm of LTS is a rhythm in learning rather than a rhythm in recall. The threshold required to elicit siphon withdrawal and the duration of siphon withdrawal were not regulated by the circadian clock. These results indicate that the circadian oscillator exerts strong modulatory influences on one form of long-term memory in Aplysia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.