ArticleJournal of virology2003
Deletions in the transmembrane domain of a sindbis virus glycoprotein alter virus infectivity, stability, and host range.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Mosquito cell-derived West Nile virus replicon particles mimic arbovirus inoculum and have reduced spread in mice.PLoS neglected tropical diseases · 2017Article
- Eilat virus host range restriction is present at multiple levels of the virus life cycle.Journal of virology · 2015Article
- Live attenuated tetravalent dengue virus host range vaccine is immunogenic in African green monkeys following a single vaccination.Journal of virology · 2014Article
- Structural differences observed in arboviruses of the alphavirus and flavivirus genera.Advances in virology · 2014Review
- Encapsidation of host-derived factors correlates with enhanced infectivity of Sindbis virus.Journal of virology · 2013Article
- Mutations of two transmembrane cysteines of hemagglutinin (HA) from influenza A H3N2 virus affect HA thermal stability and fusion activity.Virus genes · 2013Article
- Chikungunya virus host range E2 transmembrane deletion mutants induce protective immunity against challenge in C57BL/6J mice.Journal of virology · 2013Article
- Alphavirus genome delivery occurs directly at the plasma membrane in a time- and temperature-dependent process.Journal of virology · 2013Article
- Testing of novel dengue virus 2 vaccines in African green monkeys: safety, immunogenicity, and efficacy.The American journal of tropical medicine and hygiene · 2012Article
- Eilat virus, a unique alphavirus with host range restricted to insects by RNA replication.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Sindbis virus infectivity improves during the course of infection in both mammalian and mosquito cells.Virus research · 2012Article
- Conformational changes in Sindbis virus induced by decreased pH are revealed by small-angle neutron scattering.Journal of virology · 2012Article
- Molecular links between the E2 envelope glycoprotein and nucleocapsid core in Sindbis virus.Journal of molecular biology · 2011Article
- Structural mutants of dengue virus 2 transmembrane domains exhibit host-range phenotype.Virology journal · 2011Article
- The length of and nonhydrophobic residues in the transmembrane domain of dengue virus envelope protein are critical for its retention and assembly in the endoplasmic reticulum.Journal of virology · 2010Article
- The structure of Sindbis virus produced from vertebrate and invertebrate hosts as determined by small-angle neutron scattering.Journal of virology · 2010Article
- Alphavirus Entry and Membrane Fusion.Viruses · 2010Article
- Differential incorporation of cholesterol by Sindbis virus grown in mammalian or insect cells.Journal of virology · 2009Article
- Sindbis virus conformational changes induced by a neutralizing anti-E1 monoclonal antibody.Journal of virology · 2008Article
- Location and role of free cysteinyl residues in the Sindbis virus E1 and E2 glycoproteins.Journal of virology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The alphaviruses are composed of two icosahedral protein shells, one nested within the other. A membrane bilayer derived from the host cell is sandwiched between the protein shells. The protein shells are attached to one another by protein domains which extend one of the proteins of the outer shell through the membrane bilayer to attach to the inner shell. We have examined the interaction of the membrane-spanning domain of one of the membrane glycoproteins with the membrane bilayer and with other virus proteins in an attempt to understand the role this domain plays in virus assembly and function. Through incremental deletions, we have reduced the length of a virus membrane protein transmembrane domain from its normal 26 amino acids to 8 amino acids. We examined the effect of these deletions on the assembly and function of virus particles. We found that progressive truncations in the transmembrane domain profoundly affected production of infectious virus in a cyclic fashion. We also found that membrane composition effects protein-protein and protein-membrane interactions during virus assembly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.