ArticleJournal of virology2003
Endoplasmic reticulum stress is a determinant of retrovirus-induced spongiform neurodegeneration.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 80 citations in OpenAlex.
- Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes.Nutrients · 2019Review
- Endoplasmic Reticulum Stress in Arterial Smooth Muscle Cells: A Novel Regulator of Vascular Disease.Current cardiology reviews · 2017Article
- Cytoplasmic vacuolization in cell death and survival.Oncotarget · 2016Review
- Review
- Splicing of Friend Murine Leukemia Virus env-mRNA Enhances Its Ability to Form Polysomes.Frontiers in microbiology · 2016Article
- Article
- The expanding roles of endoplasmic reticulum stress in virus replication and pathogenesis.Critical reviews in microbiology · 2015Review
- Unfolded protein response in hepatitis C virus infection.Frontiers in microbiology · 2014Review
- Cellular unfolded protein response against viruses used in gene therapy.Frontiers in microbiology · 2014Review
- Article
- Role of the host cell's unfolded protein response in arenavirus infection.Journal of virology · 2011Article
- Article
- ER Stress and Iron Homeostasis: A New Frontier for the UPR.Biochemistry research international · 2011Article
- Inflammation in neurodegenerative diseases.Immunology · 2010Review
- Article
- Effects of acute and chronic murine norovirus infections on immune responses and recovery from Friend retrovirus infection.Journal of virology · 2009Article
- The degree of folding instability of the envelope protein of a neurovirulent murine retrovirus correlates with the severity of the neurological disease.Journal of virology · 2009Article
- The ubiquitin-proteasome system in spongiform degenerative disorders.Biochimica et biophysica acta · 2008Review
- Reverse genetics approaches to combat pathogenic arenaviruses.Antiviral research · 2008Review
- Sex-specific hippocampus-dependent cognitive deficits and increased neuronal autophagy in DEspR haploinsufficiency in mice.Physiological genomics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
FrCas(E) is a mouse retrovirus that causes a fatal noninflammatory spongiform neurodegenerative disease with pathological features strikingly similar to those induced by transmissible spongiform encephalopathy (TSE) agents. Neurovirulence is determined by the sequence of the viral envelope protein, though the specific role of this protein in disease pathogenesis is not known. In the present study, we compared host gene expression in the brain stems of mice infected with either FrCas(E) or the avirulent virus F43, differing from FrCas(E) in the sequence of the envelope gene. Four of the 12 disease-specific transcripts up-regulated during the preclinical period represent responses linked to the accumulation of unfolded proteins in the endoplasmic reticulum (ER). Among these genes was CHOP/GADD153, which is induced in response to conditions that perturb endoplasmic reticulum function. In vitro studies with NIH 3T3 cells revealed up-regulation of CHOP as well as BiP, calreticulin, and Grp58/ERp57 in cells infected with FrCas(E) but not with F43. Immunoblot analysis of infected NIH 3T3 cells demonstrated the accumulation of uncleaved envelope precursor protein in FrCas(E)- but not F43-infected cells, consistent with ER retention. These results suggest that retrovirus-induced spongiform neurodegeneration represents a protein-folding disease and thus may provide a useful tool for exploring the causal link between protein misfolding and the cytopathology that it causes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.