ArticleThe Journal of cell biology2003
p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed.
- Molecular Motors in Blood-Brain Barrier Maintenance by Astrocytes.Brain sciences · 2025Review
- Ubiquitination of VE-cadherin regulates inflammation-induced vascular permeability in vivo.EMBO reports · 2024Article
- How cytoskeletal crosstalk makes cells move: Bridging cell-free and cell studies.Biophysics reviews · 2024Review
- MACC1-induced migration in tumors: Current state and perspective.Frontiers in oncology · 2023Review
- Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment.Frontiers in cell and developmental biology · 2023Review
- Heterocellular N-cadherin junctions enable nontransformed cells to inhibit the growth of adjacent transformed cells.Cell communication and signaling : CCS · 2022Article
- Article
- Review
- Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.Cancer medicine · 2020Article
- The multifarious regulation of the apical junctional complex.Open biology · 2020Review
- Molecular Mechanisms of Cadherin Function During Cortical Migration.Frontiers in cell and developmental biology · 2020Review
- Microtubules: Evolving roles and critical cellular interactions.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Microtubules in cell migration.Essays in biochemistry · 2019Review
- P120 Catenin Isoforms Differentially Associate with Breast Cancer Invasion and Metastasis.Cancers · 2019Article
- Article
- A catenin-dependent balance between N-cadherin and E-cadherin controls neuroectodermal cell fate choices.Mechanisms of development · 2018Article
- Microtubule Motors in Establishment of Epithelial Cell Polarity.Cold Spring Harbor perspectives in biology · 2018Review
- The role of microtubules in the regulation of epithelial junctions.Tissue barriers · 2018Review
- A central role for cadherin signaling in cancer.Experimental cell research · 2017Review
- N-Cadherin, a novel and rapidly remodelling site involved in vasoregulation of small cerebral arteries.The Journal of physiology · 2017Article
40 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
p120 catenin (p120) is a component of adherens junctions and has been implicated in regulating cadherin-based cell adhesion as well as the activity of Rho small GTPases, but its exact roles in cell-cell adhesion are unclear. Using time-lapse imaging, we show that p120-GFP associates with vesicles and exhibits unidirectional movements along microtubules. Furthermore, p120 forms a complex with kinesin heavy chain through the p120 NH2-terminal head domain. Overexpression of p120, but not an NH2-terminal deletion mutant deficient in kinesin binding, recruits endogenous kinesin to N-cadherin. Disruption of the interaction between N-cadherin and p120, or the interaction between p120 and kinesin, leads to a delayed accumulation of N-cadherin at cell-cell contacts during calcium-initiated junction reassembly. Our analyses identify a novel role of p120 in promoting cell surface trafficking of cadherins via association and recruitment of kinesin.
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Registered trials
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