ReviewJournal of muscle research and cell motility2003
Signaling and cellular mechanisms in cardiac protection by ischemic and pharmacological preconditioning.
Review in Journal of muscle research and cell motility, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 79 citations in OpenAlex.
- Late pharmacologic conditioning with volatile anesthetics after cardiac surgery.Critical care (London, England) · 2012Trial
- Understanding the Clinical Use of Levosimendan and Perspectives on its Future in Oncology.Biomolecules · 2023Review
- Volatile Versus Intravenous Anesthetics in Cardiac Anesthesia: a Narrative Review.Current anesthesiology reports · 2021Review
- Postconditioning with Nitrates Protects Against Myocardial Reperfusion Injury: A New Use for an Old Pharmacological Agent.Medical science monitor : international medical journal of experimental and clinical research · 2020Review
- Investigating the role of acute and repeated stress on remote ischemic preconditioning-induced cardioprotection.Iranian journal of basic medical sciences · 2020Article
- The cardioprotective compound cloxyquin uncouples mitochondria and induces autophagy.American journal of physiology. Heart and circulatory physiology · 2016Article
- Sepsis protects the myocardium and other organs from subsequent ischaemic/reperfusion injury via a MAPK-dependent mechanism.Intensive care medicine experimental · 2015Article
- Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes.Biochimica et biophysica acta · 2014Article
- Inhibition of mitochondrial permeability transition pore restores the cardioprotection by postconditioning in diabetic hearts.Journal of diabetes and metabolic disorders · 2014Article
- Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury.Frontiers in physiology · 2014Review
- Enhanced charge-independent mitochondrial free Ca(2+) and attenuated ADP-induced NADH oxidation by isoflurane: Implications for cardioprotection.Biochimica et biophysica acta · 2012Article
- Mechanisms of the beneficial actions of ischemic preconditioning on subcellular remodeling in ischemic-reperfused heart.Current cardiology reviews · 2010Article
- Isoflurane preconditioning elicits competent endogenous mechanisms of protection from oxidative stress in cardiomyocytes derived from human embryonic stem cells.Anesthesiology · 2010Article
- Cardioprotection via modulation of calcium homeostasis by thiopental in hypoxia-reoxygenated neonatal rat cardiomyocytes.Yonsei medical journal · 2010Article
- Preconditioning of isoflurane on spinal cord ischemia can increase the number of inducible nitric oxide synthase-expressing motor neurons in rat.Korean journal of anesthesiology · 2010Article
- Transcriptional analysis of the mammalian heart with special reference to its endocrine function.BMC genomics · 2009Article
- Involvement of UTP in protection of cardiomyocytes from hypoxic stress.Canadian journal of physiology and pharmacology · 2009Article
- Sevoflurane and nitrous oxide exert cardioprotective effects against hypoxia-reoxygenation injury in the isolated rat heart.The journal of physiological sciences : JPS · 2009Article
- Article
- Anesthetics, immune cells, and immune responses.Journal of anesthesia · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemic preconditioning (IPC) is a defensive adaptive cellular phenomenon. Brief ischemic stimuli render the heart resistant to subsequent similar stress. Signaling for IPC and pharmacologically induced preconditioning involves several G-protein coupled cell surface receptors, second messengers, specific Ser-Thr-protein kinase-C isoforms, Tyr-kinases, and finally, results in activation of ATP-dependent potassium channels (inward rectifiers) at the sarcolemma and in the mitochondria. In cardiomyocytes these channels regulate cytosolic and mitochondrial Ca2+ levels. K+ influx into mitochondria proves to be a key factor for keeping the mitochondrial permeability transition pore closed. This ensures continuous energy production and prevents cell death by apoptosis or necrosis. Molecular structure, function, and pharmacological properties of the ATP-dependent potassium channels and of the mitochondrial permeability transition pore are discussed. Channel activating agents mimic IPC and also affect reactive oxygen species producing enzymes involved in mitochondrial respiration. Volatile anesthetics, among other drugs, mimic the cardioprotective effects of IPC. Their intracellular signaling and clinical application are briefly discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.