ArticleJournal of muscle research and cell motility2003
Cardiac expression of Gal4 causes cardiomyopathy in a dose-dependent manner.
Article in Journal of muscle research and cell motility, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation.JACC. Basic to translational science · 2025Article
- A most formidable arsenal: genetic technologies for building a better mouse.Genes & development · 2020Review
- 100-fold but not 50-fold dystrophin overexpression aggravates electrocardiographic defects in the mdx model of Duchenne muscular dystrophy.Molecular therapy. Methods & clinical development · 2016Article
- A targeted gene expression system using the tryptophan repressor in zebrafish shows no silencing in subsequent generations.Development (Cambridge, England) · 2014Article
- Efficient disruption of Zebrafish genes using a Gal4-containing gene trap.BMC genomics · 2013Article
- Gal4/UAS transgenic tools and their application to zebrafish.Zebrafish · 2008Review
- Challenges and opportunities in dystrophin-deficient cardiomyopathy gene therapy.Human molecular genetics · 2006Review
- Artificial chromosome-based transgenes in the study of genome function.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac expression of a transgene is a common approach for determining the role of gene products in the processes underlying cardiomyopathy and heart failure (HF). We have generated transgenic mice that express the 'harmless' yeast transcription factor Gal4 in the heart under control of the alpha-myosin heavy chain promoter and found that expression of this gene causes cardiomyopathy and HF, the severity of which correlated with the number of copies of the transgene integrated into the genome and with the expression level. A line with a single copy of the transgene targeted to the hprt locus correctly expressed the transgene but did not develop cardiomyopathy. Our results indicate that expression of a transgene in the heart may non-specifically cause HF in a dose-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.