Evidence map›Paper›PMID 14609027›Full record

ReviewJournal of muscle research and cell motility2003

The kinetic properties of smooth muscle: how a little extra weight makes myosin faster.

Peter Karagiannis, Frank V Brozovich

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of muscle research and cell motility, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peter KaragiannisDepartment of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA.
Frank V Brozovich
Case Western Reserve University · US

Funding

REGULATION OF SMOOTH MUSCLE CONTRACTILE PROPERTIESR01HL064137 · NHLBI · MAYO CLINIC ROCHESTER · PI BROZOVICH, FRANK V · 2000 to 2008
$2.5M
REGULATION OF VASCULAR SMOOTH MUSCLE CONTRACTIONR01HL044181 · NHLBI · MAYO CLINIC · PI BROZOVICH, FRANK V · 1997 to 2005
$2.0M
REGULATION OF VASCULAR SMOOTH MUSCLE CONTRACTIONR29HL044181 · NHLBI · GRADUATE HOSPITAL (PHILADELPHIA) · PI BROZOVICH, FRANK V · 1990 to 1994
–
NHLBI NIH HHS HL44181NHLBI NIH HHS HL64137
6 · The paper itself

Abstract

The contractile properties of smooth muscle (SM) are often described as fast and slow, but the molecular basis for the diversity in contractile properties has yet to be fully elucidated. Studies have shown that the differences in the contractile parameters are seen at the level of the contractile proteins. Experiments have implicated both the splicing of the SM myosin heavy chain (MHC) and the SM myosin essential myosin light chain as possible molecular determinants of the contractile properties of SM. This communication will focus on the role of the 7 aa insert in the smooth muscle MHC in determining the contractile properties of SM and the possible mechanism by which this insert could alter the kinetics of the SM actomyosin ATPase.

Indexed as

ActomyosinAdenosine TriphosphatasesAmino Acid SequenceAnimalsHumansKineticsModels, MolecularMuscle ContractionMuscle, SmoothMyosin Heavy ChainsMyosin Light ChainsMyosinsProtein ConformationProtein IsoformsActomyosinAdenosine TriphosphatasesMyosin Heavy ChainsMyosin Light ChainsMyosinsProtein Isoforms

Identifiers

PMID14609027
OpenAlexW31237027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.