ReviewEuropean journal of applied physiology2004
New aspects of the hormone and cytokine response to training.
Review in European journal of applied physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06295016 (Influence of Stressors and Recovery Regulation on the Super-compensation Effect of Endurance Athletes After High-intensity Intensive Training), which is not on this map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Stressors and Recovery Regulation on the Super-compensation Effect of Endurance Athletes After High-intensity Intensive Training
Who cites it
47 citing papers in PubMed, 146 citations in OpenAlex.
- Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020Trial
- Effect of multiple oral doses of androgenic anabolic steroids on endurance performance and serum indices of physical stress in healthy male subjects.European journal of applied physiology · 2006Trial
- Beyond physical exhaustion: Understanding overtraining syndrome through the lens of molecular mechanisms and clinical manifestation.Sports medicine and health science · 2025Review
- Use of phase angle as an indicator of overtraining in sport and physical training.Journal of translational medicine · 2024Review
- Molecular and biochemical investigations of the anti-fatigue effects of tea polyphenols and fruit extracts ofFrontiers in molecular biosciences · 2023Article
- The effects of physical activity on glutamate neurotransmission in neuropsychiatric disorders.Frontiers in sports and active living · 2023Review
- Effects of Physical Activity on Daily Physical Function in Chinese Middle-Aged and Older Adults: A Longitudinal Study from CHARLS.Journal of clinical medicine · 2022Article
- Platelet Activation Favours NOX2-Mediated Muscle Damage in Elite Athletes: The Role of Cocoa-Derived Polyphenols.Nutrients · 2022Article
- The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2.Medicina (Kaunas, Lithuania) · 2021Review
- Review
- Training Load Measures and Biomarker Responses during a 7-Day Training Camp in Young Cyclists-A Pilot Study.Medicina (Kaunas, Lithuania) · 2021Article
- Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats.Diabetology & metabolic syndrome · 2021Article
- Exercise-induced downregulation of serum interleukin-6 and tumor necrosis factor-alpha in Egyptian handball players.Saudi journal of biological sciences · 2021Article
- Overtraining Syndrome as a Complex Systems Phenomenon.Frontiers in network physiology · 2021Review
- Changes in γH2AX and H4K16ac levels are involved in the biochemical response to a competitive soccer match in adolescent players.Scientific reports · 2020Article
- Resistance Exercise in a Hot Environment Alters Serum Markers in Untrained Males.Frontiers in physiology · 2020Article
- Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases.Frontiers in physiology · 2018Review
- Acute and Chronic Effects of Endurance Running on Inflammatory Markers: A Systematic Review.Frontiers in physiology · 2017Article
- Psychological and Physiological Biomarkers of Neuromuscular Fatigue after Two Bouts of Sprint Interval Exercise.Frontiers in psychology · 2017Article
- Protective effects of tea polyphenols on exhaustive exercise-induced fatigue, inflammation and tissue damage.Food & nutrition research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise training is associated with peripheral-cellular and central-cerebral processes, hormonal-neuronal regulation and transmission mechanisms. During the acute training response, peripheral cellular mechanisms are mainly metabolostatic to achieve energy supply and involve associated cytokine and hormonal reactions. Glycogen deficiency is associated with increased expression of local cytokines (interleukin-6, IL-6), decreased expression of glucose transporters, increased cortisol and decreased insulin secretion and beta-adrenergic stimulation. A nutrient-sensing signal of adipose tissue may be represented by leptin which, as for insulin, IL-6 and insulin-like growth-factor I (IGF-I), has profound effects on the hypothalamus and is involved in the metabolic hormonal regulation of exercise and training. Muscle damage and repair processes may involve the expression of inflammatory cytokines (e.g. tumour necrosis factor-alpha, TNF-alpha) and of stress proteins (e.g. heat shock protein 72). During overreaching and overtraining, a myopathy-like state is observed in skeletal muscle with depressed turnover of contractile proteins (e.g. in fast-type glycolytic fibres with a concomitant increase in slow type myosins). These alterations are influenced by exercise-induced hypercortisolism, and by decreased somatotropic hormones (e.g. IGF-I). The hypothalamus integrates various error signals (metabolic, hormonal, sensory afferents and central stimuli) and therefore pituitary releasing hormones represent the functional status of an athlete and long-term hypothalamic hormonal and sympathoadrenal downregulation are some of the prominent hormonal signs of prolonged overtraining and performance incompetence syndrome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.