ReviewEuropean biophysics journal : EBJ2004
The roles of intracellular regions in the activation of voltage-dependent potassium channels.
Review in European biophysics journal : EBJ, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The role of voltage-gated ion channels in visual function and disease in mammalian photoreceptors.Pflugers Archiv : European journal of physiology · 2021Review
- Autoimmune Channelopathies at Neuromuscular Junction.Frontiers in neurology · 2019Review
- Domain structure and conformational changes in rat KV2.1 ion channel.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2014Article
- Mechanisms of activation of voltage-gated potassium channels.Acta naturae · 2014Article
- Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.Toxicology and applied pharmacology · 2011Article
- Intracellular regions of the Eag potassium channel play a critical role in generation of voltage-dependent currents.The Journal of biological chemistry · 2011Article
- Formation of heteromeric Kv2 channels in mammalian brain neurons.The Journal of biological chemistry · 2010Article
- The domain and conformational organization in potassium voltage-gated ion channels.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2009Review
- Intracellular regions of potassium channels: Kv2.1 and heag.European biophysics journal : EBJ · 2009Review
- Single particle image reconstruction of the human recombinant Kv2.1 channel.Biophysical journal · 2008Article
- Functionally active t1-t1 interfaces revealed by the accessibility of intracellular thiolate groups in kv4 channels.The Journal of general physiology · 2005Article
- Intracellular linkers are involved in Mg2+-dependent modulation of the Eag potassium channel.Channels (Austin, Tex.)Article
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1 author.
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Abstract
The involvement of the transmembrane regions S2, S3 and S4 in the activation of potassium channels by depolarization has been well clarified. However, a role of the intracellular regions in channel function is emerging. Here we review recent evidence for the roles of intracellular regions in the functioning of members of two families of channels. The Kv2.1 potassium channel, a member of the voltage activated Kv family, has long intracellular regions. By mutagenesis studies and expression in oocytes, we identify residues in both the N- and C-terminal regions that contribute to determining activation kinetics of this channel. It seems that the C-terminus wraps around the N-terminus and interacts with it functionally. The voltage-activated ether-a-go-go (eag) channels also have long intracellular regions. Despite considerable homology, eag1 and eag2 channels display different activation kinetics. By making chimeras between these channels and again expressing in oocytes, we show that residues in both the N-terminal region and the membrane-spanning region are involved in determining these differences in activation kinetics. The intracellular N- and C-terminal regions are likely to continue to prove fertile regions in future investigations into the functioning of ion channels.
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Registered trials
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