ArticleWorld journal of gastroenterology2003
Grading and staging of hepatic fibrosis, and its relationship with noninvasive diagnostic parameters.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00345605 (A Randomized, Double-Blind, Crossover Study of Sodium Phenylbutyrate and Low-Dose Arginine Compared to High-Dose Arginine Alone on Liver Function, Ureagenesis and Subsequent Nitric Oxide Production in Patients With Argininosuccinic Aciduria), which is not on this map. Cited by 29 papers.
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A Randomized, Double-Blind, Crossover Study of Sodium Phenylbutyrate and Low-Dose Arginine Compared to High-Dose Arginine Alone on Liver Function, Ureagenesis and Subsequent Nitric Oxide Production in Patients With Argininosuccinic Aciduria
Who cites it
29 citing papers in PubMed.
- Histological outcome of chronic hepatitis B in children treated with interferon alpha.World journal of gastroenterology · 2005Trial
- Effect of lamivudine treatment on plasma levels of transforming growth factor beta1, tissue inhibitor of metalloproteinases-1 and metalloproteinase-1 in patients with chronic hepatitis B.World journal of gastroenterology · 2004Trial
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- Tumor biomarkers in evaluating the severity and prognosis of idiopathic pulmonary arterial hypertension: A comprehensive analysis.Clinical and translational science · 2024Article
- Hsa_circ_0072765 knockdown inhibits proliferation, activation and migration in transforming growth factor-beta (TGF-β)-induced hepatic stellate cells (HSCs) by the miR-197-3p/TRPV3 axis.Histology and histopathology · 2023Article
- MiR-571 affects the development and progression of liver fibrosis by regulating the Notch3 pathway.Scientific reports · 2021Article
- Comparison between shear wave elastography and serological findings for the evaluation of fibrosis in chronic liver disease.Journal of ultrasonography · 2021Article
- CXCL12-CXCR4-Mediated Chemotaxis Supports Accumulation of Mucosal-Associated Invariant T Cells Into the Liver of Patients With PBC.Frontiers in immunology · 2021Article
- Mesenchymal stem cell-based Smad7 gene therapy for experimental liver cirrhosis.Stem cell research & therapy · 2020Article
- A new tumor-associated antigen prognostic scoring system for spontaneous ruptured hepatocellular carcinoma after partial hepatectomy.Cancer biology & medicine · 2018Article
- Novel Approach for Evaluation ofFrontiers in microbiology · 2016Article
- Non-invasive serum fibrosis markers: A study in chronic hepatitis.BioImpacts : BI · 2015Article
- Serum fibronectin levels in acute and chronic viral hepatitis patients.The Malaysian journal of medical sciences : MJMS · 2014Article
- Ultrasonographic scoring system score versus liver stiffness measurement in prediction of cirrhosis.Clinical and molecular hepatology · 2013Article
- Noninvasive classification of hepatic fibrosis based on texture parameters from double contrast-enhanced magnetic resonance images.Journal of magnetic resonance imaging : JMRI · 2012Article
- Clinical significance of connective tissue growth factor in hepatitis B virus-induced hepatic fibrosis.World journal of gastroenterology · 2012Article
- Tumor marker levels before and after curative treatment of hepatocellular carcinoma as predictors of patient survival.Digestive diseases and sciences · 2011Article
- Alpha-fetoprotein above normal levels as a risk factor for the development of hepatocellular carcinoma in patients infected with hepatitis C virus.Journal of gastroenterology · 2011Article
- Clinical Benefits of Biochemical Markers of Fibrosis in Egyptian Children With Chronic Liver Diseases.Gastroenterology research · 2010Article
- Determination of the relationship of serum hyaluronic Acid levels to the degree of liver fibrosis in biopsies of patients with chronic viral hepatitis B and C.Hepatitis monthly · 2010Article
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15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the grade and stage of pathology and the relationship between grading and staging of hepatic fibrosis and noninvasive diagnostic parameters.
methodsInflammatory activity and fibrosis of consecutive liver biopsies from 200 patients with chronic liver disease were determined according to the Diagnostic Criteria of Chronic Hepatitis in China, 1995. A comparative analysis was made in these patients comparing serum markers, Doppler ultrasonography, CT and/or MR imaging with the findings of liver biopsy.
resultsWith increase of inflammatory activity, the degree of fibrosis also rose. There was a close correlation between liver fibrosis and inflammatory activity. AST, GGT, albumin, albumin/globulin, ALP, AFP, hyaluronic acid, N-terminal procollagen III(P III NP), collagen type IV(Col IV), tissue inhibitors of metalloproteinases-1 (TIMP-1), alpha-2-macroglobulin, natural killer cells(NK), some parameters of Doppler ultrasonography, CT and/or MR imaging were all related to the degree of inflammatory activity. GGT, albumin, albumin/globulin, ALP, AFP, hyaluronic acid, Col IV, TIMP-1, alpha-2- macroglobulin, transforming growth factor-beta 1 (TGFbeta1), NK, some parameters of Doppler ultrasonography, CT and/or MR imaging were all related to the staging of fibrosis. By regression analysis, the parameters used in combination to differentiate the presence or absence of fibrosis were age, GGT, the parameter of blood flow of portal vein per minute, the maximum oblique diameter of right liver by B ultrasound, the wavy hepatic surface contour by CT and/or MR. The sensitivity, specificity and accuracy of the above parameters were 80.36%, 86.67%, and 81.10%, respectively.
conclusionThere is close correlation between liver fibrosis and inflammatory activity. The grading and staging of liver fibrosis are related to serum markers, Doppler ultrasonography, CT and/or MR imaging. The combination of the above mentioned noninvasive parameters are quite sensitive and specific in the diagnosis of hepatic fibrosis.
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