ArticleWorld journal of gastroenterology2003
Expression and mutation of c-kit gene in gastrointestinal stromal tumors.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Molecular imaging of gastrointestinal stromal tumor using anti-c-KIT antibody and its fragments.Journal of gastroenterology · 2025Article
- Tumor-Targeted Drug Conjugates as an Emerging Novel Therapeutic Approach in Small Cell Lung Cancer (SCLC).Cancers · 2019Review
- Altered expression of cytokeratin 7 and CD117 in transitional mucosa adjacent to human colorectal cancer.Oncology letters · 2017Article
- Relationship between gene mutations and protein expressions of PDGFR α and C-kit in gastrointestinal stromal tumors.International journal of clinical and experimental medicine · 2015Article
- Coexistence of gastrointestinal stromal tumor, esophageal and gastric cardia carcinomas.World journal of gastroenterology · 2013Article
- Article
- Synchronous gastric adenocarcinoma and gastrointestinal stromal tumor (GIST) of the stomach: a case report.World journal of surgical oncology · 2011Article
- The structural insights of stem cell factor receptor (c-Kit) interaction with tyrosine phosphatase-2 (Shp-2): an in silico analysis.BMC research notes · 2010Article
- Improved detection of KIT exon 11 duplications in formalin-fixed, paraffin-embedded gastrointestinal stromal tumors.The Journal of molecular diagnostics : JMD · 2007Article
- A novel gain of function mutant in C-kit gene and its tumorigenesis in nude mice.World journal of gastroenterology · 2005Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the expression and mutation of c-kit gene and its correlation with the clinical pathology and prognosis of gastrointestinal stromal tumors (GISTs).
methodsA total of 94 cases of GISTs, 10 leiomyomas and 2 schwannomas were studied for the expression of KIT by immunohistochemistry. The c-kit gene mutations in exon 11 of these specimens were detected by PCR-SSCP technique.
resultsOf the 94 cases of GISTs, 91 (96.8%) expressed the KIT protein. Leiomyomas and schwannomas were negative for KIT. The c-kit gene mutations of exon 11 were found in 38 out of the 94 cases of GISTs (40.4%). The mutations involved point mutations (Val560-Asp, Ile563-Met), del 557-559 and 579ins12. No mutations were detectable in benign GISTs, leiomyomas or schwannomas. The patients with mutation-positive GISTs showed more frequent recurrences, invasion and metastasis in adjacent tissues than those with mutation-negative ones.
conclusionKIT is a useful marker for diagnosis of GISTs. Mutation of the c-kit gene may play a significant role in the pathogenesis of GISTs and may be associated with poor prognosis in patients with GISTs.
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