ArticleWorld journal of gastroenterology2003
Influence factors of serum fibrosis markers in liver fibrosis.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- A meritorious integrated medical regimen for hepatic fibrosis and its complicationsFrontiers in medicine · 2022Pooled it
- [Arbutin ameliorates liver fibrosis in mice by inhibiting macrophage recruitment and regulating the Akt/NF-κB and Smad signaling pathways].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Abnormal liver function in different patients with Schistosoma japonicum.Parasitology research · 2015Article
- Serum fibronectin levels in acute and chronic viral hepatitis patients.The Malaysian journal of medical sciences : MJMS · 2014Article
- Serum hyaluronic acid as a noninvasive marker of hepatic fibrosis in chronic hepatitis B.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2008Article
- Sampling variability of computer-aided fractal-corrected measures of liver fibrosis in needle biopsy specimens.World journal of gastroenterology · 2006Article
- Noninvasive evaluation of hepatic fibrosis in children with infant hepatitis syndrome.World journal of gastroenterology · 2006Article
- Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.World journal of gastroenterology · 2006Article
- Liver fibrosis and tissue architectural change measurement using fractal-rectified metrics and Hurst's exponent.World journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo analyze the factors which influence the serum levels of hyaluronic acid (HA), type III pro-collagen (PCIII), laminin (LN) and type IV collagen (C-IV) in liver fibrosis.
methodsThe serum specimens from 141 chronic hepatitis patients were assayed for fibrosis indexes including HA, PCIII, LN and C-IV with radioimmunoassay (RIA) and liver function indexes by an automatic biochemistry analyzer. The patients were then divided into consistent group and inconsistent group. The patients'clinical manifestations were recorded, routine blood pictures were done by a blood counter and analyzer (AC-900). Liver biopsy specimens were examined path-morphologically. The inner diameters of portal vein, splenic vein and thickness of spleen were all measured by ultrasonography.
resultsSixteen patients (14.16%) had serum fibrosis indexes inconsistent with histological stage of their hepatic fibrosis. Their serum fibrosis indexes did not correlate with the stage of hepatic fibrosis (P>0.05), but were positively correlated with the grade of inflammation (chi2=12.07, P<0.05). At the same time, serum albumin (ALB) and the ratio of albumin and globulin (A/G) were significantly increased (t=3.06, P<0.01), (t=3.70, P<0.01). Serum levels of glutamic-pyruvic transaminase (ALT), glutamic-oxaloacetic transaminase (AST), gamma-glutamyl transferase (GGT) and globulin (GLB) were all significantly decreased (t=2.45, P<0.05), (t=2.33, P<0.05), (t=2.08, P<0.05), (t=3.03, P<0.01). Weary degree also decreased more obviously (chi2=7.52, P<0.05), but other clinical manifestations, routine blood indexes, serum levels of alkaline phosphatase (AKP), total bilirubin (TBIL), total protein (TP), width of main portal vein, width of splenic vein and thickness of spleen had no significant change (P>0.05).
conclusionSerum fibrosis indexes can be influenced by the grade of inflammation, some liver function indexes and clinical manifestations. Comprehensive analysis is necessary for its proper interpretation.
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