ArticleWorld journal of gastroenterology2003
Segregation analysis of hepatocellular carcinoma in a moderately high-incidence area of East China.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The correlation between novel antidiabetic agents utilization and hepatocellular carcinoma incidence in type 2 diabetes patients: a network meta-analysis.European journal of clinical pharmacology · 2025Pooled it
- Knowledge-based analyses reveal new candidate genes associated with risk of hepatitis B virus related hepatocellular carcinoma.BMC cancer · 2020Article
- Review
- Article
- Family history influences the early onset of hepatocellular carcinoma.World journal of gastroenterology · 2012Article
- Camptothecin-20(s)-O-[N-(3'α,12'α-dihydroxy-24'-carbonyl-5'β-cholan)]-lysine, a novel camptothecin analogue, induces apoptosis towards hepatocellular carcinoma SMMC-7721 cells.Molecules (Basel, Switzerland) · 2011Article
- The association of family history of liver cancer with hepatocellular carcinoma: a case-control study in the United States.Journal of hepatology · 2009Article
- Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis.World journal of gastroenterology · 2008Article
- Genetics of hepatocellular tumors.Oncogene · 2006Review
- Localization of a susceptibility locus for hepatocellular carcinoma to chromosome 4q in a hepatitis B hyperendemic area.Oncogene · 2006Article
- MR diffusion-weighed imaging of rabbit liver.World journal of gastroenterology · 2005Article
- Differential expression of genes during aflatoxin B(1)-induced hepatocarcinogenesis in tree shrews.World journal of gastroenterology · 2004Article
- HBV cccDNA in patients' sera as an indicator for HBV reactivation and an early signal of liver damage.World journal of gastroenterology · 2004Article
- Hepatocellular Carcinoma in Asia: A Challenging Situation.Euroasian journal of hepato-gastroenterologyReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimTo explore the mode of inheritance of hepatocellular carcinoma (HCC) in a moderately high-incidence area of East China.
methodsA pedigree survey was conducted in 210 families (3315 individuals) ascertained through 210 HCC probands in Haimen, Jiangsu Province. Simple segregation analysis was conducted using SEGRANB software. The probability of ascertainment (pi), segregation ratio (p), and the proportion of sporadic cases (x) were estimated. Complex segregation analysis was performed using the REGTL program of S.A.G.E. Models were fitted on the data of 3212 individuals that allowed for personal HBsAg status and variable age of onset in REGTL program.
resultsThe estimate of segregation ratio was 0.191 by SEGRANB. The probability of ascertainment was 0.0266, and the proportion of sporadic cases was 0.465. The results of complex segregation analysis showed that Mendelian autosomal recessive inheritance of a major gene that influenced the age of onset distribution of HCC, provided the best fit to the data. In the best-fitting recessive model, the frequency of the disease allele was 0.11138. HBsAg seropositive status would significantly increase the risk of developing HCC.
conclusionThese results suggest that at least one major gene is involved in the genetic predisposition to develop HCC at an earlier age of onset. The seropositive HBsAg status can significantly increase the risk of developing HCC, which provides strong support for the interaction between genetic and environmental risk factors.
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