ArticleWorld journal of gastroenterology2003
Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Applications of CRISPR-Cas9 in mitigating cellular senescence and age-related disease progression.Clinical and experimental medicine · 2025Review
- Telomere Length and Telomerase Activity as Potential Biomarkers for Gastrointestinal Cancer.Cancers · 2024Review
- Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers.Osong public health and research perspectives · 2021Article
- Long noncoding RNA SNHG1 promotes TERT expression by sponging miR-18b-5p in breast cancer.Cell & bioscience · 2021Article
- Comprehensive Assessment ofCancers · 2020Article
- Targeting Telomeres and Telomerase: Studies in Aging and Disease Utilizing CRISPR/Cas9 Technology.Cells · 2019Review
- Azidothymidine inhibits cell growth and telomerase activity and induces DNA damage in human esophageal cancer.Molecular medicine reports · 2017Article
- Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms.Frontiers in genetics · 2016Review
- None-endoscopic Screening for Esophageal Squamous Cell Carcinoma- A Review.Middle East journal of digestive diseases · 2012Review
- Serum human telomerase reverse transcriptase: a novel biomarker for breast cancer diagnosis.International journal of clinical oncology · 2011Article
- Effects of short-term exposure to inhalable particulate matter on telomere length, telomerase expression, and telomerase methylation in steel workers.Environmental health perspectives · 2011Article
- Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop.Experimental cell research · 2007Article
- Inhibitory effects of antisense phosphorothioate oligodeoxynucleotides on pancreatic cancer cell Bxpc-3 telomerase activity and cell growth in vitro.World journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate telomerase activity and hTERT, TP-1 expression and their relationships in esophageal squamous cell carcinoma (ESCC).
methodsTelomerase activity was measured in 60 ESCC tissues using telomeric repeat amplification protocol (TRAP) assay by silver staining. In situ hybridization was used for detecting hTERT and TP-1mRNA.
resultsThe telomerase activity was detected in 83.3% of ESCC tissues. The difference of telomerase activity was significant between well and poorly cancer differentiated lesions (P<0.05). The positive rate of telomerase activity was higher in patients with lymphatic metastasis than in patients without lymphatic metastasis. In cancer tissues hTERT mRNA expression was 75% and TP-1 mRNA expression was 71.7%. The expression of hTERT, TP-1 mRNA in well and poorly differentiated carcinoma was not significant. The expression of hTERT mRNA was correlated with telomerase activity, but TP-1 mRNA expression was not correlated with it.
conclusionTelomerase activity and hTERT, TP-1 mRNA expression are up-regulated in ESCC. Telomerase activity in ESCC is correlated with lymphatic metastasis and cancer differentiation. Telomerase activity may be used as a prognostic marker in ESCC. hTERT mRNA expression is correlated with telomerase activity. Enhanced hTERT mRNA expression may initially comprehend the telomerase activity level, but it is less sensitive than TRAP assay.
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