ArticleAmerican journal of human genetics2003
Predisposition locus for major depression at chromosome 12q22-12q23.2.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Lack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: a meta-analysis.PloS one · 2014Pooled it
- Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.European journal of human genetics : EJHG · 2012Pooled it
- A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.Molecular psychiatry · 2005Trial
- Disentangling the multigenerational transmissions of socioeconomic disadvantages and mental health problems by gender and across lineages: Findings from the Stockholm Birth Cohort Multigenerational Study.SSM - population health · 2023Article
- P2X7 Receptor-Related Genetic Mouse Models - Tools for Translational Research in Psychiatry.Frontiers in neural circuits · 2022Review
- Similarities and dissimilarities between psychiatric cluster disorders.Molecular psychiatry · 2021Article
- Early-life stress induces genome-wide sex-dependent miRNA expression and correlation across limbic brain areas in rats.Epigenomics · 2021Article
- Nitric Oxide Synthase Type 1 Methylation Is Associated With White Matter Microstructure in the Corpus Callosum and Greater Panic Disorder Severity Among Panic Disorder Patients.Frontiers in neurology · 2021Article
- Sex differences in the genetic architecture of depression.Scientific reports · 2020Article
- A Large Sample Survey of Tibetan People on the Qinghai-Tibet Plateau: Current Situation of Depression and Risk Factors.International journal of environmental research and public health · 2019Article
- Depression and Sleep.International journal of molecular sciences · 2019Review
- Influence of Xiaoyaosan on depressive-like behaviors in chronic stress-depressed rats through regulating tryptophan metabolism in hippocampus.Neuropsychiatric disease and treatment · 2019Article
- Genetics Factors in Major Depression Disease.Frontiers in psychiatry · 2018Review
- Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms.Molecular psychiatry · 2017Article
- Role of P2X7 Receptor in an Animal Model of Mania Induced by D-Amphetamine.Molecular neurobiology · 2016Article
- A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates.Current neuropharmacology · 2015Review
- The genetics of major depression.Neuron · 2014Review
- Ethiopathogenesis of depressive disorders.Clinical practice and epidemiology in mental health : CP & EMH · 2014Article
- A three generation study of the mental health relationships between grandparents, parents and children.BMC psychiatry · 2013Article
Corrections and comments
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Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depression disorder is a common psychiatric disease with a major economic impact on society. In many cases, no effective treatment is available. The etiology of major depression is complex, but it is clear that the disease is, to a large extent, determined genetically, especially among individuals with a familial history of major depression, presumably through the involvement of multiple predisposition genes in addition to an environmental component. As a first step toward identification of chromosomal loci contributing to genetic predisposition to major depression, we have conducted a genomewide scan by using 628 microsatellite markers on 1,890 individuals from 110 Utah pedigrees with a strong family history of major depression. We identified significant linkage to major depression in males at marker D12S1300 (multipoint heterogeneity LOD score 4.6; P=.00003 after adjustment for multiple testing). With additional markers, the linkage evidence became highly significant, with the multipoint heterogeneity LOD score at marker D12S1706 increasing to 6.1 (P=.0000007 after adjustment for multiple testing). This study confirms the presence of one or more genes involved in psychiatric diseases on the q arm of chromosome 12 and provides strong evidence for the existence of a sex-specific predisposition gene to major depression at 12q22-q23.2.
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Registered trials
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