ArticleJournal of human genetics2003
Association of a polymorphism of the dopamine receptor D4 gene with bone mineral density in Japanese men.
Article in Journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- MicroRNA-127-3p Inhibits In Vitro Osteogenesis and Dampens Trauma-Induced Heterotopic Ossification In Vivo.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Novel SNP Combination for Predictive Osteoporotic Diagnosis.International journal of molecular sciences · 2025Article
- Focusing on spinal stenosis: emerging discoveries concerning Alendronate-induced risks and genetic drug targets.Journal of orthopaedic surgery and research · 2025Article
- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
- The role of GPCRs in bone diseases and dysfunctions.Bone research · 2019Review
- The effects of dopamine receptor 2 expression on B cells on bone metabolism and TNF-α levels in rheumatoid arthritis.BMC musculoskeletal disorders · 2016Article
- Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse.Genomics · 2009Review
- Basic and clinical aspects of osteoporosis in inflammatory bowel disease.World journal of gastroenterology · 2007Review
- Molecular genetic studies of gene identification for osteoporosis: a 2004 update.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2006Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A -521C-->T polymorphism in the promoter of the dopamine receptor D4 gene (DRD4) has been associated with novelty-seeking behavior in Japanese. Given that the dopaminergic system might also play an important role in bone metabolism, the relation of the -521C-->T polymorphism of DRD4 to bone mineral density (BMD) was examined in 2,228 Japanese subjects (1,123 men; 1,105 women) who were randomly recruited to a population-based, prospective cohort study. BMD at the radius was measured by peripheral quantitative computed tomography, and that for the total body, lumbar spine, right femoral neck, right trochanter, and right Ward's triangle was measured by dual-energy X-ray absorptiometry. Genotype was determined with a fluorescence-based allele-specific DNA primer assay system. For men, BMD for the distal radius, total body, lumbar spine, trochanter, or Ward's triangle was lower in individuals with the CC genotype than in the combined group of TT and TC genotypes or in those with the TT genotype or with the TC genotype. The urinary concentration of deoxypyridinoline was slightly, but significantly, greater in men with the CC genotype than in those with the TT or TC genotypes or with the TT genotype. For women, there were no differences in BMD among -521C-->T genotypes. These results implicate DRD4 as a candidate locus for reduced BMD in Japanese men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.