ArticleHuman genetics2004
Confirmation of chromosome 7q11 locus for predisposition to intracranial aneurysm.
Article in Human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Collagen Type I Alpha 2 (COL1A2) Polymorphism Contributes to Intracranial Aneurysm Susceptibility: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2017Pooled it
- Understanding the genetics of intracranial aneurysms: A primer.Clinical neurology and neurosurgery · 2022Review
- A pilot study on biaxial mechanical, collagen microstructural, and morphological characterizations of a resected human intracranial aneurysm tissue.Scientific reports · 2021Article
- Differentially Expressed Circular RNA Profile in an Intracranial Aneurysm Group Compared with a Healthy Control Group.Disease markers · 2021Article
- Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms.Neuromolecular medicine · 2019Review
- Cerebrovascular disorders associated with genetic lesions.Cellular and molecular life sciences : CMLS · 2019Review
- A Review of the Genetics of Intracranial Berry Aneurysms and Implications for Genetic Counseling.Journal of genetic counseling · 2017Review
- Novel ELN mutation in a family with supravalvular aortic stenosis and intracranial aneurysm.European journal of medical genetics · 2017Article
- Molecular mechanisms of the formation and progression of intracranial aneurysms.Neurologia medico-chirurgica · 2015Review
- Molecular basis and genetic predisposition to intracranial aneurysm.Annals of medicine · 2014Review
- Is type I alpha 2 collagen gene responsible for intracranial aneurysm in Northeast China?Neural regeneration research · 2013Article
- Medical record and imaging evaluation to identify arterial tortuosity phenotype in populations at risk for intracranial aneurysms.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2011Article
- Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain.Frontiers in neuroscience · 2011Article
- Article
- Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23.Journal of human genetics · 2008Article
- Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes.BMC medical genetics · 2007Article
- Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.Human genetics · 2007Article
- VEGF plasma levels in non-ruptured intracranial aneurysms.Neurosurgical review · 2006Article
- The genetics of intracranial aneurysms.Journal of human genetics · 2006Review
- Is there any evidence for linkage on chromosome 17cen in affected Japanese sib-pairs with an intracranial aneurysm?Journal of human genetics · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
A significant linkage of intracranial aneurysm (IA) has recently been reported to chromosomal region 7q11 (MLS=3.22) in a genomic search of 85 Japanese nuclear families with at least two affected siblings (104 sib pairs). This region contains the elastin gene (ELN, OMIM 130160), which is a functional candidate gene for IA. We have replicated this finding through linkage analyses in 13 extended pedigrees from Utah, comprising 39 IA cases. We genotyped three markers flanking ELN and performed two-point and multipoint parametric analyses, employing simple dominant and recessive models. Analyses utilizing a recessive affecteds-only model yielded significant confirmation of linkage to the region (best evidence, multipoint TLOD=2.34, at D7S2421, corrected P=0.001). This study is the first to confirm the linkage of the 7q11 locus for IA.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.