ArticleImmunogenetics2003
Alleles carried at positions -819 and -592 of the IL10 promoter affect transcription following stimulation of peripheral blood cells with Streptococcus pneumoniae.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- IL-10 promoter polymorphism associated with decreased risk of aGvHD after stem cell transplantation: a meta-analysis.International journal of hematology · 2013Pooled it
- IL-10 gene polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis.PloS one · 2013Pooled it
- IL10 promoter variants are associated with gene expression but they are not markers of susceptibility to acute coronary syndrome.Scientific reports · 2024Article
- Host genetic variants associated with susceptibility and severity of pneumococcal pneumonia in adult patients.Pneumonia (Nathan Qld.) · 2023Article
- The Update Immune-Regulatory Role of Pro- and Anti-Inflammatory Cytokines in Recurrent Pregnancy Losses.International journal of molecular sciences · 2022Review
- Observational
- Association of IL-10 gene promoter polymorphisms with susceptibility to pseudoexfoliation syndrome, pseudoexfoliative and primary open-angle glaucoma.BMC medical genetics · 2020Article
- An association between IL-10 promoter polymorphisms and diabetic nephropathy: a meta-analysis of case-control studies.Journal of diabetes and metabolic disorders · 2018Review
- Association of Vitamin D Receptor Polymorphism with Susceptibility to Symptomatic Pertussis.PloS one · 2016Article
- Association Between IL-10 Gene Polymorphism and Diabetic Retinopathy.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Interleukin 10 gene promoter polymorphisms in women with early-onset pre-eclampsia.Clinical and experimental immunology · 2014Article
- Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria.Frontiers in immunology · 2013Article
- Association of interleukin-10 promoter polymorphism (-1082 g/a) and gastric cancer in andhra pradesh population of South India.Iranian journal of cancer prevention · 2012Article
- Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols?European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2011Article
- Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.Nature genetics · 2010Article
- A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels.European journal of human genetics : EJHG · 2010Article
- IL-2 and IL-10 gene polymorphisms are associated with respiratory tract infection and may modulate the effect of vitamin E on lower respiratory tract infections in elderly nursing home residents.The American journal of clinical nutrition · 2010Article
- Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study.AIDS (London, England) · 2010Article
- Entropy is more resistant to artifacts than bispectral index in brain-dead organ donors.Intensive care medicine · 2007Article
- Interleukin-10 promoter polymorphisms in male and female fertility and fecundity.Genes and immunity · 2006Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IL-10 inhibits the production of many pro-inflammatory cytokines. Polymorphisms in the IL10 gene promoter at positions -1082G-->A, -819C-->T and -592C-->A occur as three haplotypes, ATA, GCC and ACC. These influence several infectious and inflammatory diseases including community-acquired pneumonia, where a role for IL-10 is suggested by fluctuations in plasma levels of the cytokine. However, the effects of the haplotypes on IL-10 production are unclear. We stimulated peripheral blood mononuclear cells (PBMC) from at least five individuals homozygous for each of the three haplotypes with lipopolysaccharide (LPS, 10 microg/ml) or heat-killed Streptococcus pneumoniae (10(7)cfu/ml) and measured IL-10 mRNA by RT-PCR. Following S. pneumoniae stimulation, PBMC with the ATA haplotype had higher IL-10 mRNA levels than those with the GCC haplotype at 4 h (independent t-test; P=0.024), or the ACC haplotype at 4 h ( P<0.0001) and 8 h ( P=0.007). Following LPS stimulation, IL-10 mRNA levels were not significantly influenced by the IL10 haplotype, but similar trends were observed, consistent with the variable outcome of published studies. The results suggest that the -819 and/or -592 alleles affect transcription.
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