ArticleJournal of clinical microbiology2003
High diversity of ankA sequences of Anaplasma phagocytophilum among Ixodes ricinus ticks in Germany.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Tick-borne zoonoses in the Order Rickettsiales and Legionellales in Iran: A systematic review.PLoS neglected tropical diseases · 2018Pooled it
- TICKHUNTER: A Targeted Hybridization-Capture Sequencing Approach for the Detection and Characterization of Tick-borne Pathogens and Blood Meals.bioRxiv : the preprint server for biology · 2025Article
- Diversity ofAnimals : an open access journal from MDPI · 2024Article
- Presence ofPathogens (Basel, Switzerland) · 2023Article
- The Biological and Ecological Features of Northbound Migratory Birds, Ticks, and Tick-Borne Microorganisms in the African-Western Palearctic.Microorganisms · 2023Review
- Prevalence and Genotyping ofAnimals : an open access journal from MDPI · 2022Article
- Article
- The absence of the drhm gene is not a marker for human-pathogenicity in European Anaplasma phagocytophilum strains.Parasites & vectors · 2020Article
- A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe.Parasites & vectors · 2019Review
- Molecular identification of tick-borne pathogens in asymptomatic individuals with human immunodeficiency virus type 1 (HIV-1) infection: a retrospective study.BMC infectious diseases · 2018Article
- Epidemiology, genetic variants and clinical course of natural infections with Anaplasma phagocytophilum in a dairy cattle herd.Parasites & vectors · 2018Article
- Detecting and characterizing mixed infections with genetic variants of Anaplasma phagocytophilum in roe deer (Capreolus capreolus) by developing an ankA cluster-specific nested PCR.Parasites & vectors · 2017Article
- Candidatus Neoehrlichia mikurensis and Anaplasma phagocytophilum: prevalences and investigations on a new transmission path in small mammals and ixodid ticks.Parasites & vectors · 2014Article
- Rickettsiaceae and Anaplasmataceae infections in Ixodes ricinus ticks from urban and natural forested areas of Poland.Parasites & vectors · 2014Article
- Ixodes ricinus and Its Transmitted Pathogens in Urban and Peri-Urban Areas in Europe: New Hazards and Relevance for Public Health.Frontiers in public health · 2014Review
- Prevalence and Diversity among Anaplasma phagocytophilum Strains Originating from Ixodes ricinus Ticks from Northwest Norway.Journal of pathogens · 2014Article
- Analysis of the population structure of Anaplasma phagocytophilum using multilocus sequence typing.PloS one · 2014Article
- Anaplasma phagocytophilum strains from voles and shrews exhibit specific ankA gene sequences.BMC veterinary research · 2013Article
- Congenital infection with Anaplasma phagocytophilum in a calf in northern Germany.Acta veterinaria Scandinavica · 2013Article
- Co-infection and genetic diversity of tick-borne pathogens in roe deer from Poland.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Germany humans with acute granulocytic ehrlichiosis have not yet been described. Here, we characterized three different genes of Anaplasma phagocytophilum strains infecting German Ixodes ricinus ticks in order to test whether they differ from strains in other European countries and the United States. A total of 1,022 I. ricinus ticks were investigated for infection with A. phagocytophilum by nested PCR and sequence analysis. Forty-two (4.1%) ticks were infected. For all positive ticks, parts of the 16S rRNA and groESL genes were sequenced. The complete coding sequence of the ankA gene could be determined in 24 samples. The 16S rRNA and groESL gene sequences were as much as 100% identical to known sequences. Fifteen ankA sequences were >/=99.37% identical to sequences derived from humans with granulocytic ehrlichiosis in Europe and from a horse with granulocytic ehrlichiosis in Germany. Thus, German I. ricinus ticks most likely harbor A. phagocytophilum strains that can cause disease in humans. Nine additional sequences were clearly different from known ankA sequences. Because these newly described sequences have never been obtained from diseased humans or animals, their biological significance is currently unknown. Based on this unexpected sequence heterogeneity, we propose to use the ankA gene for further phylogenetic analyses of A. phagocytophilum and to investigate the biology and pathogenicity of strains that differ in the ankA gene.
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