ReviewCurrent pain and headache reports2003
The pathogenesis of muscle pain.
Review in Current pain and headache reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 214 citations in OpenAlex.
- Acupuncture for treating fibromyalgia.The Cochrane database of systematic reviews · 2013Pooled it
- Risk and Health Factors for Temporomandibular Disorders Following Radiotherapy for Head and Neck Cancer.Journal of oral rehabilitation · 2025Trial
- Trigger point dry needling increases masseter muscle oxygenation in patients with temporomandibular disorder.Journal of applied oral science : revista FOB · 2023Trial
- Trial
- Repetitive tooth-clenching triggers kynurenine pathway activation in masseter muscle of women with temporomandibular disorders myalgia.Pain reports · 2026Article
- Multimodal pain management in foot and ankle surgery and trauma: a narrative review.Musculoskeletal surgery · 2026Review
- Texture analysis on muscle T2 maps can reveal changes in upper trapezius muscles related to primary headache disorders.Scientific reports · 2026Article
- High Cardiorespiratory Fitness and Vigorous Physical Activity Relate to Select Pain Sensitivity Assessments in Healthy Adults: A Cross-Sectional Study.Pain research & management · 2026Article
- A conceptual framework for core stabilization training based on integrated ultrasonographic and functional evidence.Frontiers in sports and active living · 2026Article
- MuscleSCS: a standardized programming framework combining neural neuromodulation and spinally mediated paraspinal muscle modulation.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Fascial Nodal PointMedical acupuncture · 2025Article
- Myofascial Pain Syndrome: An Update on Clinical Characteristics, Etiopathogenesis, Diagnosis, and Treatment.Muscle & nerve · 2025Review
- Prevalence and location of myofascial trigger points in dogs with osteoarthritis.Frontiers in veterinary science · 2025Article
- Exploring fascia in myofascial pain syndrome: an integrative model of mechanisms.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- The Temporal Associations of Neck Pain and Headache - Implications for the Diagnostic Approach to the Myofascial Involvement in Migraine.Journal of central nervous system disease · 2025Article
- Expert opinion on heat therapy for teenagers' musculoskeletal pain management.Annals of translational medicine · 2024Review
- Exercise-induced pain within endurance exercise settings: Definitions, measurement, mechanisms and potential interventions.Experimental physiology · 2024Review
- Parietal abdominal pain with lower leg discrepancy: a case report.Journal of medical case reports · 2024Article
- Advance in the mechanism and clinical research of myalgia in long COVID.American journal of clinical and experimental immunology · 2024Review
- Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets.Scientific reports · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nociceptive nerve endings in muscles and other tissues are equipped with a multitude of receptor molecules for endogenous pain-producing and sensitizing agents. Particularly interesting molecules are the purinergic receptors, which can be activated by adenosine triphosphate (ATP), and the vanilloid receptor, which is sensitive to protons (low pH). The purinergic receptors are activated by tissue damage because cell necrosis is associated with the release of ATP. A low pH is present in many pathologic conditions such as ischemia and inflammation. At the spinal and medullar level, painful muscle lesions induce marked neuroplastic changes that result in hyperexcitability and hyperactivity of nociceptive neurons. This central sensitization is the basis for the spontaneous pain and hyperalgesia of patients. The transition from acute to chronic muscle pain is complete when the initially functional changes are transformed into structural ones. Patients with morphologic alterations in their nociceptive system are difficult to treat because the changes need time to normalize.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.