ArticleOncogene2003
Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- Genome-Wide Analysis of the GRF-GIF Module inInternational journal of molecular sciences · 2026Article
- BAF complex-independent gene activation by SS18::SSX.bioRxiv : the preprint server for biology · 2026Article
- Arabidopsis AN3 and OLIGOCELLULA genes link telomere maintenance mechanisms with cell division and expansion control.Plant molecular biology · 2024Article
- Arabidopsis AN3 and OLIGOCELLULA genes link telomere maintenance mechanisms with cell division and expansion control.Research square · 2023Article
- Whole-genome identification and expression profiling of growth-regulating factor (GRF) and GRF-interacting factor (GIF) gene families in Panax ginseng.BMC genomics · 2023Article
- Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.Nature communications · 2022Article
- Synovial Sarcoma: A Complex Disease with Multifaceted Signaling and Epigenetic Landscapes.Current oncology reports · 2020Review
- The epigenomics of sarcoma.Nature reviews. Cancer · 2020Review
- Biological roles and an evolutionary sketch of the GRF-GIF transcriptional complex in plants.BMB reports · 2019Review
- GIF Transcriptional Coregulators Control Root Meristem Homeostasis.The Plant cell · 2018Article
- The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis.Oncogene · 2016Article
- Loss of SS18-SSX1 inhibits viability and induces apoptosis in synovial sarcoma.Clinical orthopaedics and related research · 2014Article
- ANGUSTIFOLIA3 binds to SWI/SNF chromatin remodeling complexes to regulate transcription during Arabidopsis leaf development.The Plant cell · 2014Article
- Novel pathways and molecular targets for the treatment of sarcoma.Current oncology reports · 2013Review
- Truncated SSX protein suppresses synovial sarcoma cell proliferation by inhibiting the localization of SS18-SSX fusion protein.PloS one · 2013Article
- Pediatric sarcomas: translating molecular pathogenesis of disease to novel therapeutic possibilities.Pediatric research · 2012Review
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- The Arabidopsis GRF-INTERACTING FACTOR gene family performs an overlapping function in determining organ size as well as multiple developmental properties.Plant physiology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Many studies have now established that the SWI/SNF chromatin remodelling complexes are involved in activation and repression of a variety of genes. In mammalian cells, these complexes contain the BRM and BRG1 helicase-like proteins that are thought to be responsible for nucleosome remodelling. The proto-oncoprotein SYT, involved in the unique translocation t(X;18) found in synovial sarcoma, is known to interact with human BRM (hBRM), thus providing a link between chromatin remodelling factors and human cancer. In this work, we address how SYT interacts with hBRM and BRG1. We demonstrate that the conserved N-terminal SNH domain of SYT, which is also present in the oncoproteins SYT-SSX, binds to both hBRM and BRG1. We have also found that in vivo the C-terminus transactivation QPGY region of SYT can interact with itself. This results in an amplified interaction with hBRM and highlights a possible regulatory function of this domain in cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.