ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Peptidergic activation of locomotor pattern generators in the neonatal spinal cord.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Beyond lactation: Central oxytocin in maternal mental health and disease.Neuroscience and biobehavioral reviews · 2026Review
- Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets.Nature neuroscience · 2019Article
- Hypomethylation of miR-142 promoter and upregulation of microRNAs that target the oxytocin receptor gene in the autism prefrontal cortex.Molecular autism · 2015Article
- V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion.Neuron · 2014Article
- Nanomolar oxytocin synergizes with weak electrical afferent stimulation to activate the locomotor CpG of the rat spinal cord in vitro.PloS one · 2014Article
- Expression of arginine vasotocin receptors in the developing zebrafish CNS.Gene expression patterns : GEP · 2013Article
- Endogenous extracellular serotonin modulates the spinal locomotor network of the neonatal mouse.The Journal of physiology · 2010Article
- Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels.Neuroscience · 2009Article
- Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Developmental regulation of neuromodulator function in the stomatogastric ganglion of the lobster, Homarus americanus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Developmental aspects of spinal locomotor function: insights from using the in vitro mouse spinal cord preparation.The Journal of physiology · 2003Review
- Article
- Modulation of Rhythmic Activity in Mammalian Spinal Networks Is Dependent on Excitability State.eNeuroArticle
- Evidence for the presence and functioning of the spinal generator for ejaculation in the neonatal male rat.International journal of impotence researchArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of motor networks in the spinal cord is partly activity-dependent. We have observed receptor-mediated excitatory effects of two peptides, arginine vasopressin (AVP) and oxytocin (OXT), on motor network activity in the neonate. With the use of an en bloc in vitro preparation of mouse spinal cord (2-3 d old), which either was isolated completely or had muscles of the hindlimb left intact, we show that the bath application of AVP or OXT can evoke an increase in population bursting of motoneurons recorded from the lumbar ventral roots. By using antagonists for AVP and OXT, we found that these peptides were binding primarily to V1a and OXT receptors, respectively. Western blot analysis revealed a 48 kDa V1a and a 55 kDa OXT receptor immunoreactive band that was expressed in tissue obtained from L1-L6 sections of spinal cord. AVP, but not OXT, could, on occasion, evoke sustained periods of locomotor-like activity. In addition, when we applied AVP or OXT in combination with a 5-HT2 agonist, bouts of locomotor-like activity could be observed in a majority of preparations. Collectively, these data point to a novel role for AVP and OXT in the activation of spinal motor networks.
Indexed as
Identifiers
14602832PMC6740850W2122615913What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.