ArticleJournal of neurovirology2003
Cloning and initial characterization of an alternatively spliced transcript encoded by the bovine herpes virus 1 latency-related gene.
Article in Journal of neurovirology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- The Bovine Herpesvirus 1 Latency-Reactivation Cycle, a Chronic Problem in the Cattle Industry.Viruses · 2023Review
- Inhibition of Stress-Induced Viral Promoters by a Bovine Herpesvirus 1 Non-Coding RNA and the Cellular Transcription Factor, β-Catenin.International journal of molecular sciences · 2021Article
- Article
- A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with DNA.Journal of virology · 2013Article
- Bovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting Apoptosis.Journal of cell death · 2013Review
- Localization of sequences in a protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 that inhibits apoptosis and interferes with Notch1-mediated trans-activation of the bICP0 promoter.Journal of virology · 2011Article
- Regulation of the latency-reactivation cycle by products encoded by the bovine herpesvirus 1 (BHV-1) latency-related gene.Journal of neurovirology · 2011Review
- A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3.Journal of virology · 2011Article
- Small noncoding RNAs encoded within the bovine herpesvirus 1 latency-related gene can reduce steady-state levels of infected cell protein 0 (bICP0).Journal of virology · 2010Article
- The cellular transcription factor, CCAAT enhancer-binding protein alpha (C/EBP-alpha), has the potential to activate the bovine herpesvirus 1 immediate-early transcription unit 1 promoter.Journal of neurovirology · 2009Article
- Open reading frame 2, encoded by the latency-related gene of bovine herpesvirus 1, has antiapoptotic activity in transiently transfected neuroblastoma cells.Journal of virology · 2008Article
- Identification of a novel protein encoded by the latency-related gene of bovine herpesvirus 1.Journal of neurovirology · 2007Article
- A protein encoded by the bovine herpesvirus 1 latency-related gene interacts with specific cellular regulatory proteins, including CCAAT enhancer binding protein alpha.Journal of virology · 2007Article
- Localization of sequences within the latency-related gene of bovine herpesvirus 1 that inhibit mammalian cell growth.Journal of neurovirology · 2005Article
- A herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene in place of latency-associated transcript has a wild-type reactivation phenotype in the mouse.Journal of virology · 2005Article
- A mutation in the latency-related gene of bovine herpesvirus 1 inhibits protein expression from open reading frame 2 and an adjacent reading frame during productive infection.Journal of virology · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bovine herpesvirus 1 (BHV-1) establishes latency in trigeminal ganglionic sensory neurons of infected cattle. The latency-related (LR) RNA is the only abundantly expressed viral transcript in sensory neurons of latently infected calves. Wild-type expression of LR gene products is required for the latency-reactivation cycle in calves. LR RNA is alternatively spliced in trigeminal ganglia (TG) after infection of calves, suggesting that these alternatively spliced transcripts encode novel factors that regulate specific steps during latency. To begin testing whether these alternatively spliced transcripts have novel functions, the authors cloned a full-length cDNA identified in TG of calves at 7 days post infection (dpi) and compared the functions of this cDNA to the intact LR gene. As a result of splicing, the 7 dpi cDNA contains a novel open reading (ORF) comprised of OFR-2 fused to ORF-1. Overexpression of the 7 dpi cDNA inhibited the BHV-1 immediate-early transcription unit 1 (IEtu1) promoter and the herpes simplex virus type 1 ICP0 promoter. Conversely, the 7 dpi cDNA stimulated the LR promoter in transiently transfected cells. A plasmid containing the LR gene had little effect on IEtu1 or LR promoter activity, indicating that the 7 dpi cDNA has novel functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.