ArticleDevelopmental cell2003
Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila.
Article in Developmental cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 82 citations in OpenAlex.
- Harnessing the Power ofCold Spring Harbor perspectives in biology · 2026Review
- Review
- Exploring the molecular pathways of miRNAs in testicular cancer: from diagnosis to therapeutic innovations.Functional & integrative genomics · 2025Review
- Ras promotes germline stem cell division in Drosophila ovaries.Stem cell reports · 2024Article
- The journey of a generation: advances and promises in the study of primordial germ cell migration.Development (Cambridge, England) · 2024Article
- Hedgehog signaling guides migration of primordial germ cells to the Drosophila somatic gonad.Genetics · 2023Article
- Imaginal disk growth factors are Drosophila chitinase-like proteins with roles in morphogenesis and CO2 response.Genetics · 2023Article
- Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation.Nature ecology & evolution · 2022Article
- Integration of Transcriptomic and Proteomic Analyses Reveals New Insights into the Regulation of Immune Pathways in Midgut ofInsects · 2022Article
- Revealing phosphorylation regulatory networks during embryogenesis of honey bee worker and drone (Frontiers in cell and developmental biology · 2022Article
- Transcriptional Inhibition ofInternational journal of molecular sciences · 2020Article
- Reactive oxygen species signaling in primordial germ cell development in Drosophila embryos.Genesis (New York, N.Y. : 2000) · 2020Article
- Setting up for gastrulation: D. melanogaster.Current topics in developmental biology · 2020Review
- Expressional Profiling of Carpet Glia in the DevelopingFrontiers in neuroscience · 2019Article
- Article
- Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis.International journal of molecular sciences · 2018Review
- Transcriptional quiescence in primordial germ cells.Critical reviews in biochemistry and molecular biology · 2018Review
- Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred.Experimental eye research · 2018Article
- K-RAS and N-RAS mutations in testicular germ cell tumors.Bosnian journal of basic medical sciences · 2017Article
- Reconstitution of Torso signaling in cultured cells suggests a role for both Trunk and Torso-like in receptor activation.Development (Cambridge, England) · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Primordial germ cells (PGCs) undergo proliferation, invasion, guided migration, and aggregation to form the gonad. Here we show that in Drosophila, the receptor tyrosine kinase Torso activates both STAT and Ras during the early phase of PGC development, and coactivation of STAT and Ras is required for PGC proliferation and invasive migration. Embryos mutant for stat92E or Ras1 have fewer PGCs, and these cells migrate slowly, errantly, and fail to coalesce. Conversely, overactivation of these molecules causes supernumerary PGCs, their premature transit through the gut epithelium, and ectopic colonization. A requirement for RTK in Drosophila PGC development is analogous to the mouse, in which the RTK c-kit is required, suggesting a conserved molecular mechanism governing PGC behavior in flies and mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.