ReviewTransgenic research2003
The transgenic rabbit as model for human diseases and as a source of biologically active recombinant proteins.
Review in Transgenic research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 73 citations in OpenAlex.
- Transgenesis in Drug Discovery: Enhancing Target Identification and Validation.Molecular biotechnology · 2026Review
- Use of Genome Editing Techniques to Produce Transgenic Farm Animals.Advances in experimental medicine and biology · 2022Review
- Therapeutic Effects of Natural Compounds and Small Molecule Inhibitors Targeting Endoplasmic Reticulum Stress in Alzheimer's Disease.Frontiers in cell and developmental biology · 2021Review
- Hyperhomocysteinemia and dyslipidemia in point mutation G307S of cystathionine β-synthase-deficient rabbit generated using CRISPR/Cas9.Lipids in health and disease · 2020Article
- Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2.Cellular and molecular life sciences : CMLS · 2020Article
- CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy.Computational and structural biotechnology journal · 2020Review
- Generation and Phenotype Identification ofG3 (Bethesda, Md.) · 2018Article
- A novel rabbit model of Duchenne muscular dystrophy generated by CRISPR/Cas9.Disease models & mechanisms · 2018Article
- Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits.Analytical cellular pathology (Amsterdam) · 2018Article
- Rabbit Models for Studying Human Infectious Diseases.Comparative medicine · 2015Review
- Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9.Experimental animals · 2015Article
- Expression systems and species used for transgenic animal bioreactors.BioMed research international · 2013Article
- Transgenic rabbit models for studying human cardiovascular diseases.Comparative medicine · 2012Review
- Modeling human neurodegenerative diseases in transgenic systems.Human genetics · 2012Review
- Generation of SV40-transformed rabbit tracheal-epithelial-cell-derived blastocyst by somatic cell nuclear transfer.Cell and tissue research · 2012Article
- The genetic structure of domestic rabbits.Molecular biology and evolution · 2011Article
- Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine.The Journal of biological chemistry · 2010Article
- High level expression of tissue-nonspecific alkaline phosphatase in the milk of transgenic rabbits.Transgenic research · 2006Article
- Increased transgene integration efficiency upon microinjection of DNA into both pronuclei of rabbit embryos.Transgenic research · 2005Article
- Construction of a cytogenetically anchored microsatellite map in rabbit.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Until recently, transgenic rabbits were produced exclusively by pronuclear microinjection which results in additive random insertional transgenesis; however, progress in somatic cell cloning based on nuclear transfer will soon make it possible to produce rabbits with modifications to specific genes by the combination of homologous recombination and subsequent prescreening of nuclear donor cells. Transgenic rabbits have been found to be excellent animal models for inherited and acquired human diseases including hypertrophic cardiomyopathy, perturbed lipoprotein metabolism and atherosclerosis. Transgenic rabbits have also proved to be suitable bioreactors for the production of recombinant protein both on an experimental and a commercial scale. This review summarizes recent research based on the transgenic rabbit model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.