ArticleJournal of muscle research and cell motility1992
Myosin heavy chain composition of single fibres and their origins and distribution in developing fascicles of sheep tibialis cranialis muscles.
Article in Journal of muscle research and cell motility, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 81 citations in OpenAlex.
- Developmental Programming and Postnatal Modulations of Muscle Development in Ruminants.Biology · 2025Review
- Decoding the prenatal clock of sheep muscle fiber type differentiation: a temporal map from embryonic to mature types.Frontiers in cell and developmental biology · 2025Article
- Restricted maternal nutrition and supplementation of propylene glycol, monensin sodium and rumen-protected choline chloride during late pregnancy does not affect muscle fibre characteristics of offspring.Veterinary medicine and science · 2023Article
- Dousing the flame: reviewing the mechanisms of inflammatory programming during stress-induced intrauterine growth restriction and the potential for ω-3 polyunsaturated fatty acid intervention.Frontiers in physiology · 2023Review
- Primary myoblasts from intrauterine growth-restricted fetal sheep exhibit intrinsic dysfunction of proliferation and differentiation that coincides with enrichment of inflammatory cytokine signaling pathways.Journal of animal science · 2022Article
- Going Up Inflame: Reviewing the Underexplored Role of Inflammatory Programming in Stress-Induced Intrauterine Growth Restricted Livestock.Frontiers in animal science · 2021Article
- Maternal Undernutrition during Pregnancy Alters Amino Acid Metabolism and Gene Expression Associated with Energy Metabolism and Angiogenesis in Fetal Calf Muscle.Metabolites · 2021Article
- MiR-27b promotes sheep skeletal muscle satellite cell proliferation by targetingJournal of genetics · 2018Article
- Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development.Scientific reports · 2016Article
- Intrauterine growth-restricted sheep fetuses exhibit smaller hindlimb muscle fibers and lower proportions of insulin-sensitive Type I fibers near term.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Myoblasts from intrauterine growth-restricted sheep fetuses exhibit intrinsic deficiencies in proliferation that contribute to smaller semitendinosus myofibres.The Journal of physiology · 2014Article
- Knockdown of endogenous myostatin promotes sheep myoblast proliferation.In vitro cellular & developmental biology. Animal · 2014Article
- Co-expression analysis of fetal weight-related genes in ovine skeletal muscle during mid and late fetal development stages.International journal of biological sciences · 2014Article
- Poor maternal nutrition inhibits muscle development in ovine offspring.Journal of animal science and biotechnology · 2014Article
- Recent progress in histochemistry and cell biology.Histochemistry and cell biology · 2012Review
- Developmental programming in response to intrauterine growth restriction impairs myoblast function and skeletal muscle metabolism.Journal of pregnancy · 2012Review
- Histological and transcriptome-wide level characteristics of fetal myofiber hyperplasia during the second half of gestation in Texel and Ujumqin sheep.BMC genomics · 2011Article
- Potential sources of early-postnatal increase in myofibre number in pig skeletal muscle.Histochemistry and cell biology · 2011Article
- A gene network switch enhances the oxidative capacity of ovine skeletal muscle during late fetal development.BMC genomics · 2010Article
- Effects of hypothyroidism on myosin heavy chain composition and fibre types of fast skeletal muscles in a small marsupial, Antechinus flavipes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The myosin heavy chain (MHC) composition of single muscle fibres in developing sheep tibialis cranialis muscles was examined immunohistochemically with monoclonal antibodies to MHC isozymes. Data were collected with conventional microscopy and computerized image analysis from embryonic day (E) 76 to postnatal day (PN) 20, and from adult animals. At E76, 23% of the young myofibres stained for slow-twitch MHC. The number of these fibres considerably exceeded the number of primary and secondary myotubes. By E100, smaller fibres, negative for slow-twitch MHC, encircled each fibre from the initial population to form rosettes. A second population of small fibres appeared in the unoccupied spaces between rosettes. Small fibres, whether belonging to rosettes or not, did not initially express slow-twitch MHC, expressing mainly neonatal myosin instead. These small fibres then diverged into three separate groups. In the first group most fibres transiently expressed adult fast myosin (maximal at E110-E120), but in the adult expressed slow myosin. This transformation to the slow MHC phenotype commenced at E110, was nearing completion by 20 postnatal days, and was responsible for approximately 60% of the adult slow twitch fibre population. In the other two groups expression of adult fast MHC was maintained, and in the adult they accounted for 14% (IIa MHC) and 17% (IIb MHC) of the total fibre numbers. We conclude that muscle fibre formation in this large muscle involves at least three generations of myotube. Secondary myotubes are generated on a framework of primary myotubes and both populations differentiate into the young myofibres which we observed at E76 to form rosettes. Tertiary myotubes, in turn, appear in the spaces between rosettes and along the borders of fascicles, using the outer fibres of rosettes as scaffolds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.