ArticleJournal of muscle research and cell motility1992
Effects of 2,3-butanedione monoxime on the crossbridge kinetics in frog single muscle fibres.
Article in Journal of muscle research and cell motility, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Effects of chemical myosin II cross-bridge inhibitors on eccentric force production in skinned muscle fibres.Experimental physiology · 2026Article
- Non-cross Bridge Viscoelastic Elements Contribute to Muscle Force and Work During Stretch-Shortening Cycles: Evidence From Whole Muscles and Permeabilized Fibers.Frontiers in physiology · 2021Article
- Effects of myosin inhibitors on the X-ray diffraction patterns of relaxed and calcium-activated rabbit skeletal muscle fibers.Biophysics and physicobiology · 2018Article
- Robust mechanobiological behavior emerges in heterogeneous myosin systems.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The active force-length relationship is invisible during extensive eccentric contractions in skinned skeletal muscle fibres.Proceedings. Biological sciences · 2017Article
- X-ray diffraction analysis of the effects of myosin regulatory light chain phosphorylation and butanedione monoxime on skinned skeletal muscle fibers.American journal of physiology. Cell physiology · 2016Article
- Poorly understood aspects of striated muscle contraction.BioMed research international · 2015Review
- Effects of eugenol on resting tension of rat atria.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin.The Journal of biological chemistry · 2009Article
- Effects of the number of actin-bound S1 and axial force on X-ray patterns of intact skeletal muscle.Biophysical journal · 2006Article
- Crossbridge properties investigated by fast ramp stretching of activated frog muscle fibres.The Journal of physiology · 2005Article
- Effects of a myosin-II inhibitor (N-benzyl-p-toluene sulphonamide, BTS) on contractile characteristics of intact fast-twitch mammalian muscle fibres.Journal of muscle research and cell motility · 2005Article
- Cycling cross-bridges increase myocardial stiffness at submaximal levels of Ca2+ activation.Biophysical journal · 2003Article
- Effects of 2,3-butanedione monoxime on excitation-contraction coupling in frog twitch fibres.Journal of muscle research and cell motility · 1998Article
- Detachment of low-force bridges contributes to the rapid tension transients of skinned rabbit skeletal muscle fibres.The Journal of physiology · 1997Article
- Effects of 2,3-butanedione monoxime on cross-bridge kinetics in rat cardiac muscle.Pflugers Archiv : European journal of physiology · 1996Article
- Tension relaxation after stretch in resting mammalian muscle fibers: stretch activation at physiological temperatures.Biophysical journal · 1996Article
- Mechanochemical coupling in muscle: attempts to measure simultaneously shortening and ATPase rates in myofibrils.Biophysical journal · 1996Article
- BDM compared with P(i) and low Ca2+ in the cross-bridge reaction initiated by flash photolysis of caged ATP.Biophysical journal · 1995Article
- Ca(2+)- and GTP[gamma S]-induced translocation of the glucose transporter, GLUT-4, to the plasma membrane of permeabilized cardiomyocytes determined using a novel immunoprecipitation method.Pflugers Archiv : European journal of physiology · 1995Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of 2,3-butanedione monoxime (BDM) on contraction characteristics were studied at 5 degrees C in single intact fibres isolated from the tibialis anterior muscle of the frog. The force-velocity relation was determined using the controlled-velocity method in either whole fibres or short fibre segments in which sarcomere shortening was measured by a laser light diffraction method. It is shown that 3 mM BDM decreases the speed of rise and the amount of tetanus tension, reduces the maximum velocity of shortening and increases the curvature of the force-velocity relation, as well as the value for the stiffness to tension ratio. BDM also slowed down the redevelopment of tetanus tension after a period of unloaded shortening both in fixed-end and in length-clamp conditions. In normal and in BDM-treated fibres length-clamping increased the speed of the initial rise of tetanus tension but not that of the recovery after shortening. The observed force-velocity data points were fitted by the Huxley (1957) equation. It was found that BDM produces a conspicuous decrease of the rate constant for crossbridge attachment. This effect, and also a reduction of the force per crossbridge, are responsible for the depression of the contractile characteristics produced by BDM.
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