ArticleThe Journal of cell biology2003
Avidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- Dynamic biochemical tissue analysis detects functional selectin ligands on human cancer tissues.Scientific reports · 2019Article
- Sex Differences in Mouse Popliteal Lymph Nodes.Scientific reports · 2019Article
- Single molecule and multiple bond characterization of catch bond associated cytoadhesion in malaria.Scientific reports · 2017Article
- Reinforcement of integrin-mediated T-Lymphocyte adhesion by TNF-induced Inside-out Signaling.Scientific reports · 2016Article
- Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands.British journal of pharmacology · 2013Review
- Shear-stabilized rolling behavior of E. coli examined with simulations.Biophysical journal · 2010Article
- Article
- Targeted delivery of therapeutics to endothelium.Cell and tissue research · 2009Review
- Selectin catch-slip kinetics encode shear threshold adhesive behavior of rolling leukocytes.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Cooperativity in adhesion cluster formation during initial cell adhesion.Biophysical journal · 2008Article
- A structure-based sliding-rebinding mechanism for catch bonds.Biophysical journal · 2007Article
- Adhesive dynamics simulations of the shear threshold effect for leukocytes.Biophysical journal · 2007Article
- Synapses: sites of cell recognition, adhesion, and functional specification.Annual review of biochemistry · 2007Review
- Transport governs flow-enhanced cell tethering through L-selectin at threshold shear.Biophysical journal · 2007Article
- Flow-enhanced adhesion regulated by a selectin interdomain hinge.The Journal of cell biology · 2006Article
- Catch-bond model derived from allostery explains force-activated bacterial adhesion.Biophysical journal · 2006Article
- L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibited.The American journal of pathology · 2005Article
- Force history dependence of receptor-ligand dissociation.Biophysical journal · 2005Article
- Catch bonds govern adhesion through L-selectin at threshold shear.The Journal of cell biology · 2004Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
L-selectin is a key lectin essential for leukocyte capture and rolling on vessel walls. Functional adhesion of L-selectin requires a minimal threshold of hydrodynamic shear. Using high temporal resolution videomicroscopy, we now report that L-selectin engages its ligands through exceptionally labile adhesive bonds (tethers) even below this shear threshold. These tethers share a lifetime of 4 ms on distinct physiological ligands, two orders of magnitude shorter than the lifetime of the P-selectin-PSGL-1 bond. Below threshold shear, tether duration is not shortened by elevated shear stresses. However, above the shear threshold, selectin tethers undergo 14-fold stabilization by shear-driven leukocyte transport. Notably, the cytoplasmic tail of L-selectin contributes to this stabilization only above the shear threshold. These properties are not shared by P-selectin- or VLA-4-mediated tethers. L-selectin tethers appear adapted to undergo rapid avidity enhancement by cellular transport, a specialized mechanism not used by any other known adhesion receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.